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Local Lymph Node Assay

Known as: LLNA 
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and… 
National Institutes of Health

Papers overview

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2017
2017
The role of glutathione in Allergic Contact Dermatitis
.................................................................................................................................. vi Chapter 1: General Introduction .............................................................................................. 1 Chapter 2: Materials and Methods. ....................................................................................... 45 Chapter 3: Modulation of GSH oxido-reduction mechanism in the HaCaT cell line. ............. 66 Chapter 4: GSH conjugation as clearance mechanism of dinitrohalobenzenes in the HaCaT cell line. .................................................................................................................................. 99 Chapter 5: GSH conjugation of model sensitisers of various potencies: Case study for DNCB, DPCP and DEM. .................................................................................................................... 123 Chapter 6: Effect of multiple dosing of DNCB on the Reconstructed Human Epidermis model. .................................................................................................................................. 155 Chapter 7: General Discussion. ............................................................................................ 181 Bibliography. ........................................................................................................................ 190 
2014
2014
Predicting Skin Sensitization Using ToxCast Assays
Allergic contact dermatitis (ACD) is an adverse health effect from repeated exposure to skin-sensitizing chemicals and products… 
2011
2011
Evaluation of the murine local lymph node assay ( LLNA ) for assessing the allergic contact dermatitis hazard potential of pesticide formulations
In 2010 a panel of scientific experts was tasked with assessing the availability of alternative methods to animal testing for… 
2010
2010
Comparison of Responses in the Murine Local Lymph Node Assay ( LLNA ) Between CBA and BALB / c Mouse Strains
While CBA is currently the recommended strain for the LLNA, the assay was originally developed using BALB/c mice. Since the… 
2009
2009
Internationally Harmonized Performance Standards for the Murine Local Lymph Node Assay (LLNA)
National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)/National… 
2009
2009
Potency Values from the Local Lymph Node Assay : Application to Classification , Labelling and Risk Assessment Document
2007
2007
Utilization of irritation data in the local lymph node assay
2005
2005
Lecture SAR meets LLNA – Structure Activity Relationship triggers the Local Lymph Node Assay for testing the skin sensitisation potential
ALTEX 22, Special Issue 2005 269 Recent years have seen a growing emphasis towards the use of computational methods, such as… 
2002
2002
Local lymph node assay with non-radioisotope alternative endpoints.
The local lymph node assay has recently been accepted by regulatory agencies as a stand-alone alternate method for predicting… 
Review
1999
Review
1999
National Institute of Environmental Health Sciences (NIEHS); the Murine Local Lymph Node Assay: a Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds, report…
The report entitled "The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of…