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Local Lymph Node Assay

Known as: LLNA 
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and… 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction.
2006
2006
The local lymph node assay in practice: a current regulatory perspective
Following the formal acceptance of the local lymph node assay (LLNA) as an Organization for Economic Cooperation and Development… 
Highly Cited
2006
Highly Cited
2006
Evaluation of immunomodulation by Lactobacillus casei Shirota: immune function, autoimmunity and gene expression.
2005
2005
Novel approach for classifying chemicals according to skin sensitizing potency by non‐radioisotopic modification of the local lymph node assay
The murine local lymph node assay (LLNA) is currently recognized as a stand‐alone sensitization test for determining the… 
2002
2002
Local lymph node assay with non-radioisotope alternative endpoints.
The local lymph node assay has recently been accepted by regulatory agencies as a stand-alone alternate method for predicting… 
Highly Cited
2002
Highly Cited
2002
Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay.
A modified local lymph node assay (LLNA) with ex vivo tritium thymidine (3H-TdR) labeling of the proliferating lymph node cells… 
Highly Cited
2001
Highly Cited
2001
Human potency predictions for aldehydes using the local lymph node assay
The murine local lymph node assay (LLNA) assesses skin sensitization potential as a function of proliferative responses induced… 
1999
1999
Local lymph node assay: differentiating allergic and irritant responses using flow cytometry.
The murine local lymph node assay (LLNA) is a method for assessing the contact sensitization potential of chemicals. Based on… 
Review
1998
Review
1998
Strategies for identifying false positive responses in predictive skin sensitization tests.
Highly Cited
1989
Highly Cited
1989
The murine local lymph node assay for identification of contact allergens: a preliminary evaluation of in situ measurement of lymphocyte proliferation
A murine local lymph node assay for the identification of contact allergens has been developed. Contact sensitizing activity is… 
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