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Local Lymph Node Assay

Known as: LLNA 
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and… 
National Institutes of Health

Papers overview

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2009
2009
Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA).
Genomic technologies have the potential to enhance and complement existing toxicology endpoints; however, assessment of these… 
Review
2007
Review
2007
The Local Lymph Node Assay: Current Position in the Regulatory Classification of Skin Sensitizing Chemicals
The local lymph node assay (LLNA) is being used increasingly in the identification of skin sensitizing chemicals for regulatory… 
2006
2006
The local lymph node assay and skin sensitization: a cut‐down screen to reduce animal requirements?
The local lymph node assay (LLNA), an alternative approach to skin‐sensitizing testing, has made a significant contribution to… 
Highly Cited
2005
Highly Cited
2005
Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line.
2005
2005
Novel approach for classifying chemicals according to skin sensitizing potency by non‐radioisotopic modification of the local lymph node assay
The murine local lymph node assay (LLNA) is currently recognized as a stand‐alone sensitization test for determining the… 
2002
2002
Local lymph node assay with non-radioisotope alternative endpoints.
The local lymph node assay has recently been accepted by regulatory agencies as a stand-alone alternate method for predicting… 
Highly Cited
2000
Highly Cited
2000
Comparison of mouse strains using the local lymph node assay.
Highly Cited
1999
Highly Cited
1999
Influence of application vehicle on skin sensitization to methylchloroisothiazolinone/methylisothiazolinone: an analysis using the local lymph node assay
The murine local lymph node assay (LLNA) is a method for the identification of skin sensitizing chemicals in which activity is… 
1999
1999
Local lymph node assay: differentiating allergic and irritant responses using flow cytometry.
The murine local lymph node assay (LLNA) is a method for assessing the contact sensitization potential of chemicals. Based on… 
1993
1993
Evaluation of contact sensitivity of rubber chemicals using the murine local lymph node assay
The sensitizing abilities of 4 rubber additives, tetramelhylthiuram disulfide (TMTD), 2‐mercaplob‐enzothiazole (MBT), V‐isopropyl… 
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