• Publications
  • Influence
Physiological implications of sterol biosynthesis in yeast.
Fungi are among the most primitive organisms that synthesize sterols. The fungal sterol, ergosterol, is similar to animal sterol, cholesterol, but with significant structural differences. TheExpand
  • 300
  • 12
Screening Chemicals for Estrogen Receptor Bioactivity Using a Computational Model.
The U.S. Environmental Protection Agency (EPA) is considering high-throughput and computational methods to evaluate the endocrine bioactivity of environmental chemicals. Here we describe a multistep,Expand
  • 151
  • 9
  • PDF
Fluorescent microsphere‐based readout technology for multiplexed human single nucleotide polymorphism analysis and bacterial identification
Large‐scale human genotyping requires technologies with a minimal number of steps, high accuracy, and the ability to automate at a reasonable cost. In this regard, we have developed a rapid,Expand
  • 144
  • 4
Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway
The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist and antagonistExpand
  • 99
  • 3
Prediction of skin sensitization potency using machine learning approaches
The replacement of animal use in testing for regulatory classification of skin sensitizers is a priority for US federal agencies that use data from such testing. Machine learning models that classifyExpand
  • 25
  • 3
  • PDF
Development and Validation of a Computational Model for Androgen Receptor Activity
Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods.Expand
  • 84
  • 2
  • PDF
Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae.
Using yeast strains with null mutations in structural genes which encode delta-aminolevulinic acid synthetase (HEM1), isozymes of 3-hydroxy-3-methylglutaryl coenzyme A (HMG1 and HMG2), squaleneExpand
  • 47
  • 2
  • PDF
A Curated Database of Rodent Uterotrophic Bioactivity
Background: Novel in vitro methods are being developed to identify chemicals that may interfere with estrogen receptor (ER) signaling, but the results are difficult to put into biological contextExpand
  • 68
  • 2
  • PDF
Application of Adverse Outcome Pathways to U.S. EPA’s Endocrine Disruptor Screening Program
Background: The U.S. EPA’s Endocrine Disruptor Screening Program (EDSP) screens and tests environmental chemicals for potential effects in estrogen, androgen, and thyroid hormone pathways, and it isExpand
  • 41
  • 2
  • PDF
Report on the international workshop on alternatives to the murine histamine sensitization test (HIST) for acellular pertussis vaccines: state of the science and the path forward.
Regulatory authorities require safety and potency testing prior to the release of each production lot of acellular pertussis (aP)-containing vaccines. Currently, the murine histamine sensitizationExpand
  • 8
  • 2
  • PDF