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Liter Per Hour Per Square Meter

Known as: (l/h)/m2, L/h/m2, Liters per Hour per Square Meter 
A unit expressed as one liter of volume per unit of time equal to one hour per square meter of area.
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2007
Highly Cited
2007
A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic…
SummaryPurpose: SNS-032, (formerly BMS-387032) is a potent and selective inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9… Expand
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2007
2007
F-ara-A pharmacokinetics during reduced-intensity conditioning therapy with fludarabine and busulfan
Fludarabine is commonly used in combination with busulfan as part of conditioning regimens before allogeneic stem cell… Expand
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Highly Cited
2004
Highly Cited
2004
Pharmacokinetics of liposomal doxorubicin (TLC-D99; Myocet) in patients with solid tumors: an open-label, single-dose study
PurposeLiposomal encapsulation of doxorubicin is designed to increase safety and tolerability by decreasing cardiac and… Expand
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2004
2004
Lack of effect of aprepitant on the pharmacokinetics of docetaxel in cancer patients
BackgroundAprepitant is a selective neurokinin-1 receptor antagonist that is effective for the prevention of nausea and vomiting… Expand
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Highly Cited
2001
Highly Cited
2001
Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients.
BACKGROUND Previous work demonstrated that 5-fluorouracil (5-FU) metabolism is a critical factor for treatment tolerability. In… Expand
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2001
2001
Phase I dose-finding and pharmacokinetic trial of irinotecan (CPT-11) administered every two weeks.
OBJECTIVES This trial was performed to determine the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and… Expand
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Highly Cited
2000
Highly Cited
2000
Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients.
The aim of this study was to investigate the clinical pharmacokinetics of 5-fluorouracil (5-FU) and its major metabolite 5-fluoro… Expand
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2000
2000
Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers.
SAM486A (previously termed CGP 48664), a potent inhibitor of S-adenosylmethionine decarboxylase, is under clinical development… Expand
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1992
1992
A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 days.
Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein… Expand
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1988
1988
Pharmacokinetics and metabolism of pirarubicin in advanced cancer patients.
We have studied the pharmacokinetics and metabolism of pirarubicin (4'-O-tetrahydropyranyldoxorubicin) in six patients included… Expand
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