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Methylphenidate hydrochloride given with or before breakfast: II. Effects on plasma concentration of methylphenidate and ritalinic acid.
Few differences between the "fed" and "fasted" states were noted, but the statistically significant differences indicated that meals accelerate rather than impede the absorption of methylphenidate.
Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy.
This pilot study suggests that most retinoblastomas are curable by combining chemotherapy with cyclosporine therapy, laser therapy, and cryotherapy, without requiring external beam radiotherapy.
High-pressure liquid chromatographic analysis of indocyanine green.
The development of a specific high-pressure liquid chromatographic (HPLC) assay, having a quantitative detection limit of 0.4 microgram/ml, is described for plasma indocyanine green, which points to the possibility of metabolite formation of the dye in vivo.
Methylphenidate hydrochloride given with or before breakfast
Gas chromatographic/mass spectrometric analysis of methylphenidate (ritalin) in serum.
Cloxacillin absorption and disposition in cystic fibrosis.
Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation.
- H. Chan, G. Deboer, B. Gallie
- MedicineClinical cancer research : an official journal of…
- 1 September 1996
It is suggested that cyclosporin improves the long-term response of retinoblastoma to chemotherapy, possibly by more than one mechanism.
Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer
Cyclophosphamide, methotrexate, and 5-fluorouracil pharmacokinetic data from one treatment would not be useful information from which the doses for subsequent courses could be determined.
Determination of Fostriecin Pharmacokinetics in Plasma Using High‐Pressure Liquid Chromatography Assay
Fostriecin is an antitumor antibiotic with marked activity against ovarian, breast, and lung cancer cell lines in the human tumor clonogenic assay and in vitro it has been shown to inhibit macromolecular synthesis, interact with the reduced folate carrier system, and inhibit topoisomerase II.
Ethanol vapor above skin: determination by a gas sensor instrument and relationship with plasma concentration.
- H. G. Giles, S. Meggiorini, Y. Israel
- MedicineAlcoholism, clinical and experimental research
- 1 June 1987
Studies with a new instrument show that blood ethanol concentrations in rats and humans can be estimated by measurement of ethanol vapor above the skin, and skin vapor measurements are comparable with breathalyzer determinations in controlled studies.