Leukemic Cell

Malignant hematopoietic cell originating in the clonal proliferation of myeloid or lymphoid precursor that undergoes an aberrant and poorly regulated… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per… (More)
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Highly Cited
2008
Highly Cited
2008
The host tissue microenvironment influences malignant cell proliferation and metastasis, but little is known about how tumor… (More)
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Highly Cited
2007
Highly Cited
2007
gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy… (More)
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Highly Cited
2006
Highly Cited
2006
The NOTCH1 signaling pathway directly links extracellular signals with transcriptional responses in the cell nucleus and plays a… (More)
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Highly Cited
2005
Highly Cited
2005
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant… (More)
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Highly Cited
2002
Highly Cited
2002
In clinical trials, the tyrosine kinase inhibitor STI571 has proven highly effective in reducing leukemic cell burden in chronic… (More)
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Highly Cited
2000
Highly Cited
2000
Emerging data suggest that VEGF receptors are expressed by endothelial cells as well as hematopoietic stem cells. Therefore, we… (More)
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Highly Cited
1998
Highly Cited
1998
The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR-4 (fusin, LESTR) are likely to be involved in the… (More)
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Highly Cited
1998
Highly Cited
1998
The leukemic B lymphocytes from chronic lymphocytic leukemic (CLL) patients have a long survival in vivo, although ex vivo they… (More)
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Highly Cited
1977
Highly Cited
1977
Sixty-two explants from peripheral blood, bone marrow and cerebral fluid of children with acute lymphoblastic leukemia (ALL) and… (More)
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