FAQ

Leukemia, Myeloid, Chronic-Phase

Known as: Chronic Phase CML, Myelogenous Leukemia, Chronic, Chronic-Phase, Leukemia, Granulocytic, Chronic-Phase 
A phase of chronic myelogenous leukemia in which the peripheral blood smear shows leukocytosis due mainly to neutrophils in different stages of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1943-2018
010203019432017

Related topics

Related topics

23 relations
ABL1 geneAnemiaBCR-ABL Fusion GeneBone Marrow
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Leukemia, Myeloid, Chronic-Phase
cancer cell
Anemia
Fatigue
Bone Marrow
radiotherapeutic

Papers overview

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Highly Cited
2012
Highly Cited
2012
Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia.
We characterized leukemia stem cells (LSC) in chronic phase chronic myelogenous leukemia (CML) using a transgenic mouse model… (More)
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Highly Cited
2007
Highly Cited
2007
Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.
BACKGROUND Imatinib mesylate treatment causes remissions in a majority of patients with chronic myeloid leukemia (CML), but… (More)
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2007
2007
Drug treatment is superior to allografting as first-line therapy in chronic myeloid leukemia.
Early allogeneic hematopoietic stem cell transplantation (HSCT) has been proposed as primary treatment modality for patients with… (More)
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Highly Cited
2006
Highly Cited
2006
Gene expression changes associated with progression and response in chronic myeloid leukemia.
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease with distinct biological and clinical features. The biologic… (More)
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Highly Cited
2005
Highly Cited
2005
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and…
PURPOSE Point mutations within the ABL kinase domain of the BCR-ABL gene have been associated with clinical resistance to… (More)
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Highly Cited
2004
Highly Cited
2004
High-dose imatinib mesylate therapy in newly diagnosed Philadelphia chromosome-positive chronic phase chronic myeloid leukemia.
Imatinib mesylate (STI571) is effective in chronic phase chronic myelogenous leukemia (CML). However, most patients treated with… (More)
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Highly Cited
2004
Highly Cited
2004
Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs.
Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia… (More)
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Highly Cited
2003
Highly Cited
2003
Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon alfa plus low-dose cytarabine: results from the IRIS Study.
PURPOSE Quality of life (QOL) outcomes in patients with chronic myeloid leukemia (CML) were evaluated in an international phase… (More)
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Highly Cited
1998
Highly Cited
1998
High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase.
We have previously shown that intravenously injected peripheral blood (PB) or bone marrow (BM) cells from newly diagnosed chronic… (More)
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Highly Cited
1991
Highly Cited
1991
T-cell depletion of HLA-identical transplants in leukemia.
We analyzed the effects of T-cell depletion on the outcome of HLA-identical sibling bone marrow transplants for leukemia by… (More)
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