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Let-7

Known as: hsa-let-7, MIRLET7, Let-7 miRNA 
A microRNA that has seven isofoms and is known to be a regulator of the RAS oncogene. The length of the miRNA is ~22 nucleotides, and the 3' UTR is… 
National Institutes of Health

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Homo sapiensMIRLET7E Pre-miRNAMIRLET7E geneMIRLET7E wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution
Objective— Infantile hemangiomas (IHs) are the most common benign vascular neoplasms of infancy, characterized by a rapid growth… 
2016
2016
MicroRNA Expression Profiling to Identify and Validate Reference Genes for the Relative Quantification of microRNA in Rectal Cancer
Introduction MicroRNAs (miRNAs) play important roles in regulating biological processes at the post-transcriptional level… 
2015
2015
Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease
This study examined the expression patterns of serum let-7 microRNA (miRNA) and its target gene, pepsinogen C (PGC), in gastric… 
2015
2015
A novel mechanism of LIN-28 regulation of let-7 microRNA expression revealed by in vivo HITS-CLIP in C. elegans
The evolutionarily conserved gene lin-28 encodes an RNA-binding protein and is an important regulator of the proper temporal… 
2015
2015
MicroRNA let-7g cooperates with interferon/ribavirin to repress hepatitis C virus replication
MicroRNAs (miRNA) have been implicated in HCV infection. The present study analyzed the effects of let-7g on HCV infection in… 
2014
2014
MicroRNA let-7g and let-7i inhibit hepatoma cell growth concurrently via downregulation of the anti-apoptotic protein B-cell lymphoma-extra large
Let-7 family members have been identified as tumor-suppressing microRNAs, which are important in human hepatocellular carcinoma… 
2013
2013
A let-7 KRAS rs712 polymorphism increases colorectal cancer risk
Growing evidence has indicated that polymorphism present in the miRNA binding site of target gene can alter the ability of miRNAs… 
2010
2010
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
To detect the expression levels of the lethal-7 (let-7) and K-ras genes in non-small cell lung cancer (NSCLC) and investigate… 
2008
2008
Regulation of the Drosophila lin‐41 homologue dappled by let‐7 reveals conservation of a regulatory mechanism within the LIN‐41 subclade
Drosophila Dappled (DPLD) is a member of the RBCC/TRIM superfamily, a protein family involved in numerous diverse processes such… 
2008
2008
Identification of specific let-7 microRNA binding complexes in Caenorhabditis elegans.
Little is known about the protein complexes required for microRNA formation and function. Here we used native gel electrophoresis… 
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