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The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection.
Cecropins are antibacterial peptides that are synthesized in insects as a response to infection. As a first step towards a molecular study of the induction of this response, we have isolated genomic…
A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes
- Marco Gallio, Gwen M. Sturgill, P. Rather, P. Kylsten
- BiologyProceedings of the National Academy of Sciences…
- 9 September 2002
This study provides the first evidence that prokaryotic and eukaryotic RHOs could have a conserved role in cell communication and that their biochemical properties could be more similar than previously anticipated.
The andropin gene and its product, a male‐specific antibacterial peptide in Drosophila melanogaster.
It appears that insects have evolved a mechanism for the protection of the seminal fluid and the male reproductive tract against microbial infections.
Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: A pentacoordinated binding of the SCN− ion to the zinc at high pH
- A. Eriksson, P. Kylsten, T. Jones, A. Liljas
- ChemistryProteins: Structure, Function, and Bioinformatics
- 15 January 1990
The binding of four inhibitors—mercuric ion, 3‐acetoxymercuri‐4‐aminobenzenesulfonamide (AMS), acetazolamide (Diamox), and thiocyanate ion—to human carbonic anhydrase II (HCA II) has been studied…
The lysozyme locus in Drosophila melanogaster: an expanded gene family adapted for expression in the digestive tract
Rather than being a component of the haemolymph, the Drosophila lysozymes are found mainly in the digestive tract where they are expressed at a high level, and all genes, except LysP, encode acidic proteins, in contrast to the strongly basic “typical” ly sozymes.
Regulation of the Drosophila lin‐41 homologue dappled by let‐7 reveals conservation of a regulatory mechanism within the LIN‐41 subclade
- F. O'Farrell, Shiva Seyedoleslami Esfahani, Y. Engström, P. Kylsten
- BiologyDevelopmental dynamics : an official publication…
- 1 January 2008
Drosophila Dappled (DPLD) is a member of the RBCC/TRIM superfamily, a protein family involved in numerous diverse processes such as developmental timing and asymmetric cell divisions. DPLD belongs to…
Rhomboid-7 over-expression results in Opa1-like processing and malfunctioning mitochondria.
The lysozyme locus in Drosophila melanogaster: different genes are expressed in midgut and salivary glands
- P. Kylsten, D. Kimbrell, S. Daffre, C. Samakovlis, D. Hultmark
- BiologyMolecular and General Genetics MGG
- 1 April 1992
In contrast to the bacteria-induced lysozymes in the hemolymph of many insects, the transcription levels of both Drosophila genes decrease after bacterial injections into the hemocoel, suggesting that these gene products have been recruited for the digestion of bacteria present in fermenting food.
The immune response in Drosophila: pattern of cecropin expression and biological activity.
A useful in vitro system to study the immune response has been found in Schneider's line 2 cells which respond to lipopolysaccharide and laminarin by cecropin expression.
Ribosome activity and modification of 16S RNA are influenced by deletion of ribosomal protein S20
It is suggested that two modified bases, m5C and m62A, are directly or indirectly essential for association of subunits to functional ribosomes in the rpsT mutant strain.