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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
TLDR
It is shown that let-7 is a heterochronic switch gene that encodes a temporally regulated 21-nucleotide RNA that is complementary to elements in the 3′ untranslated regions of the heteroch chronic genes lin-14, lin-28, Lin-41, lin -42 and daf-12, indicating that expression of these genes may be directly controlled by let- 7.
Oncomirs — microRNAs with a role in cancer
TLDR
Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
TLDR
Two small RNAs regulate the timing of Caenorhabditis elegans development and may control late temporal transitions during development across animal phylogeny.
The let-7 microRNA represses cell proliferation pathways in human cells.
TLDR
This work reveals the let-7 microRNA to be a master regulator of cell proliferation pathways and shows that multiple genes involved in cell cycle and cell division functions are also directly or indirectly repressed byLet-7.
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
TLDR
These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes.
The let-7 family of microRNAs.
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
TLDR
Recent advances in the understanding of miRNAs in cancer and in other diseases are described and the challenge of identifying the most efficacious therapeutic candidates is discussed and a perspective on achieving safe and targeted delivery of miRNA therapeutics is provided.
Small non-coding RNAs in animal development
TLDR
Improved understanding of the biological functions of small non-coding RNAs has been fostered by the analysis of genetic deletions of individual miRNAs in mammals, and studies show that miRNA are key regulators of animal development and are potential human disease loci.
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