Ledakrin
National Institutes of Health
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An antitumour DNA cross-linking drug, ledakrin, and other antitumour 1-nitro-9-aminoacridines applied to HeLa S3 cells caused a…
For the anticancerous derivative of acridine--Ledakrin C-283 [1-nitro-9-(3-dimethylaminopropylamino)-acridine . 2HCl-H2O] 1H and…
Ledakrin (Nitracrine) and its three analogues (C-846, C-857, C-1006) selected in primary in vitro and in vivo screening systems…
Ledakrin, 1-nitro-9-[3'-(N,N'-dimethyl)aminopropyl]aminoacridine administered intraperitoneally at a dose up to 20 mg/kg into…
In the presence of sulfhydryl compounds, an anticancer drug 1-nitro-9-(3-N,N-dimethylaminopropylamino) acridine (nitracrine…
Mutagenic activity of Ledakrin in microbial testing as well as its inductive effect on the release of free phages in lysogenic…
The authors observed changes in activity of leucine amino-peptidase (E.C. 3.4.1.1--LAP), gamma-glutamyl transpeptidase (F.C 2.3.2…
1. Ledakrin (C-283), a 1-nitro-9-aminopropylacridine derivative, inhibits RNA synthesis in vitro if the complex with DNA is…