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Large-Scale Sequencing

The process of determining of the precise sequence of nucleotides over a very large piece of DNA, possibly the entire genome of an organism.
National Institutes of Health

Papers overview

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2015
2015
Bioinformatics computation of metabolic models from sequenced genomes
In the early days of the human genome project (HGP), during the late 1980s and early 1990s, there was skepticism that the genome… 
2014
2014
Evaluating the Coverage and Potential of Imputing the Exome Microarray with Next-Generation Imputation Using the 1000 Genomes Project
Next-generation genotyping microarrays have been designed with insights from large-scale sequencing of exomes and whole genomes… 
2013
2013
Making connections: using networks to stratify human tumors
Network-based stratification (NBS) enables the subtyping of tumors on the basis of their mutational profiles, providing new… 
2013
2013
Plasma-derived tumor DNA analysis at whole-genome resolution.
The last 2 years have witnessed an extraordinary change in our understanding of the somatic mutational landscape of solid tumors… 
Review
2011
Review
2011
[Advances in actinobacterial systematics in genomic era].
Actinobacteria is one of the best studied taxa of prokaryotes due to its great importance in biotechnology, medical science… 
2009
2009
Research Highlights
49 assemble a eubacterial genome from short DNA fragment reads without the use of a reference genome—a process referred to as de… 
2007
2007
Analysis of Large-Scale Sequencing of Small RNAs
The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs… 
2005
2005
Gene expression profile in rat pancreatic islet and RINm5F cells.
To clarify tissue-specificity of pancreatic beta cells, comparison of mRNA expression in various conditions of the tissue of… 
2005
2005
Gene expression profile in rat pancreatic islet and RINm 5 F cells
To clarify tissue-specificity of pancreatic cells, comparison of mRNA expression in various conditions of the tissue of multiple… 
1992
1992
Efficient large-scale sequencing of the Escherichia coli genome: implementation of a transposon- and PCR-based strategy for the analysis of ordered lambda phage clones.
We have developed a strategy for efficient sequence analysis of the genome of E. coli K-12 using insertions of a Tn5-derived mini… 
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