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Large-Scale Sequencing

The process of determining of the precise sequence of nucleotides over a very large piece of DNA, possibly the entire genome of an organism.
National Institutes of Health

Papers overview

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2018
2018
Differential viral accessibility (DIVA) identifies alterations in chromatin architecture through large-scale mapping of lentiviral integration sites
Alterations in chromatin structure play a major role in the epigenetic regulation of gene expression. Here, we describe a step-by… 
Highly Cited
2014
Highly Cited
2014
The ice-binding proteins of a snow alga, Chloromonas brevispina: probable acquisition by horizontal gene transfer
All ice-and snow-related unicellular algae examined so far secrete ice-binding proteins (IBPs) to mitigate freezing damage. Two… 
2013
2013
Making connections: using networks to stratify human tumors
Network-based stratification (NBS) enables the subtyping of tumors on the basis of their mutational profiles, providing new… 
2007
2007
Analysis of Large-Scale Sequencing of Small RNAs
The advent of large-scale sequencing has opened up new areas of research, such as the study of Piwi-interacting small RNAs… 
2007
2007
Isolation of 1,796 SSR clones from SSR-enriched DNA libraries of bunching onion (Allium fistulosum)
Bunching onion (Allium fistulosum L.) is one of the most important vegetables in Japan. To establish a genetic basis for… 
2004
2004
Biologists think bigger
Developments in academia and industry may encourage biologists to use large-scale computation 
Highly Cited
2003
Highly Cited
2003
Large-scale analysis of the meningococcus genome by gene disruption: resistance to complement-mediated lysis.
The biologic role of a majority of the Neisseria meningitidis 2100 predicted coding regions is still to be assigned or… 
2003
2003
Transcriptome study in China.
1997
1997
Las Vegas algorithms for gene recognition: suboptimal and error-tolerant spliced alignment
Recently, Gelfand, Mironov and Pevzner (1996) proposed a spliced alignment approach to gene recognition that provides 99… 
Highly Cited
1993
Highly Cited
1993
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing.
The concept of sequencing by hybridization (SBH) makes use of an array of all possible n-nucleotide oligomers (n-mers) to… 
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