Lamivudine

Known as: 3TC, 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-, 2',3'-Dideoxy-3'-thiacytidine 
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
BACKGROUND & AIMS The GLOBE trial has compared the efficacy and safety of telbivudine versus lamivudine treatment over 2 years in… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
To the Editor: We would like to raise four points with respect to the report by Lai et al. (Dec. 20, 2007, issue)1 on the 1-year… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
BACKGROUND Treatment of HBeAg-positive patients with chronic hepatitis B is not effective in most. A combination of… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND The effectiveness of antiviral therapy in preventing disease progression in patients with chronic hepatitis B and… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Available treatments for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B are associated with poor sustained… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND AND AIMS Adefovir dipivoxil possesses potent in vitro and in vivo antiviral activity in wild-type hepatitis B. This… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS One year of lamivudine for chronic hepatitis B results in histologic improvement. We aimed to assess the… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS Although the nucleoside analogue lamivudine has shown promise in patients with chronic hepatitis B, long… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
BACKGROUND AND METHODS In preliminary trials, lamivudine, an oral nucleoside analogue, has shown promise for the treatment of… (More)
  • figure 1
  • figure 2
  • table 3
Is this relevant?
Highly Cited
1997
Highly Cited
1997
BACKGROUND The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with… (More)
Is this relevant?