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Lamivudine

Known as: 3TC, 2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2R-cis)-, 2',3'-Dideoxy-3'-thiacytidine 
A synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active… 
National Institutes of Health

Related topics

Related topics

33 relations

Broader (3)

Anti-HIV AgentsHividZalcitabine

Narrower (9)

CombivirEpivirEpzicomGR-109714X
Hepatitis BIn BloodLamivudine / Nevirapine / StavudineLamivudine 100 MG Oral Tablet [Epivir HBV]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
NEW CONSTRAINTS ON THE EVOLUTION OF THE STELLAR-TO-DARK MATTER CONNECTION: A COMBINED ANALYSIS OF GALAXY–GALAXY LENSING, CLUSTERING, AND STELLAR MASS FUNCTIONS FROM z = 0.2 to z = 1
Using data from the COSMOS survey, we perform the first joint analysis of galaxy–galaxy weak lensing, galaxy spatial clustering… 
Highly Cited
2007
Highly Cited
2007
Formulation and evaluation of ethosomes for transdermal delivery of lamivudine
The purpose of the present research was to investigate the mechanism for improved intercellular and intracellular drug delivery… 
Highly Cited
2007
Highly Cited
2007
Telbivudine versus lamivudine in patients with chronic hepatitis B.
BACKGROUND Reducing hepatitis B virus (HBV) replication to minimal levels is emerging as a key therapeutic goal for chronic… 
Highly Cited
2007
Highly Cited
2007
Stress-strain model for concrete confined by FRP composites
Highly Cited
2000
Highly Cited
2000
Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trial
BACKGROUND, AIM, AND METHODS Alpha interferon is the generally approved therapy for HBe antigen positive patients with chronic… 
Highly Cited
2000
Highly Cited
2000
Long‐term therapy of chronic hepatitis B with lamivudine
Lamivudine therapy induces improvements in chronic hepatitis B in a high proportion of patients, but prolonged therapy is limited… 
Highly Cited
1998
Highly Cited
1998
Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group.
Cirrhosis and hepatocellular carcinoma occur as long-term complications of chronic hepatitis B virus (HBV) infection. Antiviral… 
Highly Cited
1996
Highly Cited
1996
Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine
We describe mutations in the hepatitis B virus (HBV) polymerase gene in viruses which reactivated in two patients during therapy… 
Highly Cited
1996
Highly Cited
1996
Mutation in HBV RNA‐dependent DNA polymerase confers resistance to lamivudine in vivo
The (‐) enantiomer of 3′‐thiacytidine (lamivudine) has been found to be a potent inhibitor of hepatitis B virus (HBV) and human… 
Highly Cited
1969
Highly Cited
1969
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components.
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