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LY335979

Known as: LY 335979 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

zosuquidar trihydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates
2014
2014
The inhibitory and combinative mechanism of HZ08 with P-glycoprotein expressed on the membrane of Caco-2 cell line.
Highly Cited
2011
Highly Cited
2011
Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1)
Tamoxifen is widely prescribed to patients with estrogen receptor-positive breast cancer, and it is a prodrug that requires… 
2008
2008
Role of xenobiotic efflux transporters in resistance to vincristine.
2005
2005
Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours
AbstractBackgroundZosuquidar (LY335979) is an oral P-glycoprotein modulator. This phase I study was designed to determine the… 
Highly Cited
2004
Highly Cited
2004
Contributions of CYP3A4, P-glycoprotein, and Serum Protein Binding to the Intestinal First-Pass Extraction of Saquinavir
Using CYP3A4-expressing Caco-2 cell monolayers, we assessed the roles of CYP3A4-mediated metabolism, P-glycoprotein (P-gp… 
Review
2004
Review
2004
New Insights into Drug Absorption: Studies with Sirolimus
Sirolimus is a recently marketed immunosuppressant that, in common with cyclosporine and tacrolimus, exhibits a low average oral… 
2003
2003
A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)
Abstract Purpose. To develop a population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of zosuquidar… 
2002
2002
Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity.
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized barriers to… 
1998
1998
Liquid chromatography/nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry identification of novel metabolites of the multidrug resistance modulator LY335979 in rat…
Compound LY335979 is a P-glycoprotein inhibitor currently entering phase I clinical trials for potential reversal of multidrug… 
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