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LY335979

Known as: LY 335979 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
PurposeTo determine if concomitant administration of docetaxel plus zosuquidar.3HC1 can prolong progression-free survival in… Expand
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Highly Cited
2004
Highly Cited
2004
Purpose: Our intention was to (a) to investigate the safety and tolerability of a potent P-glycoprotein modulator, zosuquidar… Expand
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Highly Cited
2003
Highly Cited
2003
Our study examines the ability of LY335979 (Zosuquidar trihydrochloride) to modulate 3 distinct ABC transporters that are… Expand
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Highly Cited
2003
Highly Cited
2003
The adequate distribution of STI-571 (Gleevec) to the central nervous system (CNS) is critical for its effective use in CNS… Expand
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2003
2003
We determined the effect of zosuquidar·3HCl, an inhibitor of P-gp, on the penetration of the anticancer drug paclitaxel into the… Expand
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2001
2001
Resistance to chemotherapy by some human tumors may be due to overexpression of membrane-associated transport proteins. The best… Expand
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Review
2001
Review
2001
Multidrug resistance may be conferred by P-glycoprotein (Pgp, ABCB1) or the multidrug resistance associated protein (MRP). These… Expand
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Highly Cited
1999
Highly Cited
1999
Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers… Expand
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1997
1997
The above data indicate that LY335979 displays the following characteristics of an 'ideal modulator' of Pgp-mediated multidrug… Expand
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Highly Cited
1996
Highly Cited
1996
Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR… Expand
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