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Purpose: Our intention was to (a) to investigate the safety and tolerability of a potent P-glycoprotein modulator, zosuquidar… Expand BACKGROUND
Multidrug resistance (MDR) is a significant obstacle to providing effective chemotherapy to many patients… Expand Our study examines the ability of LY335979 (Zosuquidar trihydrochloride) to modulate 3 distinct ABC transporters that are… Expand The adequate distribution of STI-571 (Gleevec) to the central nervous system (CNS) is critical for its effective use in CNS… Expand We determined the effect of zosuquidar·3HCl, an inhibitor of P-gp, on the penetration of the anticancer drug paclitaxel into the… Expand Multidrug resistance may be conferred by P-glycoprotein (Pgp, ABCB1) or the multidrug resistance associated protein (MRP). These… Expand Resistance to chemotherapy by some human tumors may be due to overexpression of membrane-associated transport proteins. The best… Expand Overexpression of ATP-dependent drug efflux pumps, P-glycoprotein (Pgp) or multidrug resistance-associated protein (MRP), confers… Expand The above data indicate that LY335979 displays the following characteristics of an 'ideal modulator' of Pgp-mediated multidrug… Expand Overexpression of P-glycoprotein (Pgp) by tumors results in multidrug resistance (MDR) to structurally unrelated oncolytics. MDR… Expand