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zosuquidar trihydrochloride

Known as: (2R)-anti-5-(3-(4-(10,11-difluoromethanodibenzo-suber-5-yl)piperazin-1-yl)2-hydroxypropoxy)quinoline trihydrochloride, (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, Trihydrochloride 
A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

DibenzocycloheptenesQuinolines

Narrower (1)

LY335979
Zosuquidarcytarabine/daunorubicin/zosuquidar trihydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Interakce inhibitorů tyrosinových kinas s lékovými transportéry
Tyrosinkinasove inhibitory (TKI) představuji skupinu modernich protinadorových leciv schopných inhibovat receptorove i… 
2008
2008
Gateways to clinical trials.
(-)-Epigallocatechin gallate, (-)-Gossypol; Ad.hIFN-beta, AF-37702, Agatolimod sodium, Agomelatine, Alvocidib hydrochloride, ARC… 
2007
2007
Modulation of P-glycoprotein by zosuquidar trihydrochloride.
P-glycoprotein (P-gp), a major contributor in multidrug resistance (MDR), is a cell surface drug efflux pump restricting the… 
2006
2006
pyridine Trihydrochloride ( KW-5805 ) on Gastric Acid Secretion in Rats
KVV-5805, 5-[2-(diethylamino)ethyl]amino-5,11-dihydro[1 ]benzoxepi no[3,4-b]pyridine trihydrochloride, is a new tricyclic… 
Review
2005
Review
2005
Hoechst 33342 induced limited but highly specific single-strand breaks on YEpG DNA in the presence of calf thymus DNA Topo
A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor and antimicrobial activities. We show that… 
2003
2003
Zosuquidar trihydrochloride: Multidrug resistance modulator P-glycoprotein (MDR-1) inhibitor
The plasma membrane glycoprotein, P-gicoprotein (Pgp), is thought to be the major cause of clinical resistance to certain… 
1993
1993
Antisecretory effects of a novel and long-lasting histamine H2-receptor antagonist, YM-14471, in rats and dogs.
We investigated some properties of YM-14471 (2-2(-[2-(diaminomethyleneamino)thiazol-4-yl]methylthio)ethy l-5-[3- (diethylamino… 
1980
1980
[Effect of 4-acetyl-4-(3-chlorophenyl)-1-[3-(4-methylpiperazin)-propyl] piperidine trihydrochloride on the central nervous system, cardiovascular system and isolated organs of experimental animals].
Highly Cited
1978
Highly Cited
1978
Diacridines, bifunctional intercalators. Chemistry and antitumor activity.
The synthesis and the characterization of a number of diacridines connected through the 9-amino position of the acridine rings by… 
1975
1975
Spasmoanalgesic properties of 4-propionyl-4--(3-chlorphenyl)-1-[3-(4-methylpiperazine)-propyl (-piperidine)] trihydrochloride.
The paper describes the biological activity and pharmacological properties, particularly the spasmolytic and analgesis effects…