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zosuquidar trihydrochloride

Known as: (2R)-anti-5-(3-(4-(10,11-difluoromethanodibenzo-suber-5-yl)piperazin-1-yl)2-hydroxypropoxy)quinoline trihydrochloride, (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, Trihydrochloride 
A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

DibenzocycloheptenesQuinolines

Narrower (1)

LY335979
Zosuquidarcytarabine/daunorubicin/zosuquidar trihydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats
Dependence is a hallmark feature of opiate addiction and is defined by the emergence of somatic and affective withdrawal signs… 
Highly Cited
2011
Highly Cited
2011
Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1)
Tamoxifen is widely prescribed to patients with estrogen receptor-positive breast cancer, and it is a prodrug that requires… 
2003
2003
A population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of a novel MDR modulator, zosuquidar trihydrochloride (LY335979)
Abstract Purpose. To develop a population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of zosuquidar… 
Highly Cited
2001
Highly Cited
2001
Effects of WAY100635, a selective 5-HT1A-receptor antagonist on the micturition-reflex pathway in the rat.
5-Hydroxytryptamine (5-HT) receptors in the central nervous system have been implicated in the control of micturition. The… 
Highly Cited
2000
Highly Cited
2000
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis
Purpose: Cyclooxygenase-2 (COX-2) is involved in antiapoptosis signaling, and its induction may require activation of protein… 
1999
1999
The 5-HT1A receptor agonist Bay x 3702 inhibits apoptosis induced by serum deprivation in cultured neurons.
Highly Cited
1997
Highly Cited
1997
Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]WAY-100635
Highly Cited
1997
Highly Cited
1997
Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe.
Highly Cited
1994
Highly Cited
1994
Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain.
Highly Cited
1978
Highly Cited
1978
Diacridines, bifunctional intercalators. Chemistry and antitumor activity.
The synthesis and the characterization of a number of diacridines connected through the 9-amino position of the acridine rings by… 
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