zosuquidar trihydrochloride

Known as: (2R)-anti-5-(3-(4-(10,11-difluoromethanodibenzo-suber-5-yl)piperazin-1-yl)2-hydroxypropoxy)quinoline trihydrochloride, (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, Trihydrochloride 
A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The serine/threonine kinase Akt is a downstream target of dopamine receptor signaling that is inhibited/dephosphorylated in… (More)
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2006
2006
BACKGROUND/AIM Biliary epithelial cells possess an innate immune system consisting of Toll-like receptors (TLRs). Although the… (More)
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Highly Cited
2004
Highly Cited
2004
Aripiprazole,7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-carbostycil (OPC-14597), a novel atypical… (More)
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2003
2003
We determined the effect of zosuquidar·3HCl, an inhibitor of P-gp, on the penetration of the anticancer drug paclitaxel into the… (More)
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2003
2003
Abstract Purpose. To develop a population pharmacokinetic model for doxorubicin and doxorubicinol in the presence of zosuquidar… (More)
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2000
2000
Multidrug resistance (MDR1) P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and breast cancer resistance… (More)
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Highly Cited
1997
Highly Cited
1997
The distribution of 5-HT1A receptors was examined in the post-mortem human brain using whole hemisphere autoradiography and the… (More)
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Highly Cited
1995
Highly Cited
1995
WAY-100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride) is an achiral… (More)
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1995
1995
Systemic administration of R(+)-8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), a selective serotonin (5-hydroxy-tryptamine… (More)
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Highly Cited
1981
Highly Cited
1981
Sir: In testing the activity of culture filtrates to inhibit focus formation of chicken fibroblasts by Rous sarcoma virus, an… (More)
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