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LY317615.HCl

Known as: LY-317615, LY317615 
National Institutes of Health

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2 relations

Broader (2)

enzastaurinenzastaurin hydrochloride

Papers overview

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2014
2014
Rho / ROCK and PKC pathways are involved in nfluenza-induced cytoskeletal rearrangement and hyperpermeability n PMVEC via phosphorylating ERM
Severe influenza infections are featured by acute lung injury, a syndrome of pulmonary microvascular leak. A growing number of… 
2011
2011
[11C]enzastaurin, the first design and radiosynthesis of a new potential PET agent for imaging of protein kinase C.
2010
2010
Enzastaurin (LY317615), a protein kinase C beta selective inhibitor, enhances antiangiogenic effect of radiation.
2009
2009
Molecular targeting of the PKC‐β inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression
The protein kinase C (PKC) pathway has been shown to play a role in the regulation of cell proliferation in several… 
2007
2007
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro soft-agar cloning experiments
Enzastaurin (LY317615.HCl) is an antiproliferative agent targeted specifically against PKC-beta. We have investigated the… 
2007
2007
Safety, Tolerability, QTc Evaluation, and Pharmacokinetics of Single and Multiple Doses of Enzastaurin HCl (LY317615), a Protein Kinase C‐β Inhibitor, in Healthy Subjects
The safety, tolerability, and pharmacokinetics of orally administered enzastaurin were evaluated in 2 placebo‐controlled, dose… 
Highly Cited
2006
Highly Cited
2006
Enzastaurin (LY317615), a protein kinase Cβ inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines
Enzastaurin (LY317615), an acyclic bisindolylmaleimide, is an oral inhibitor of the protein kinase Cβ isozyme. The objective of… 
Highly Cited
2004
Highly Cited
2004
Protein Kinase CβII Regulates Its Own Expression in Rat Intestinal Epithelial Cells and the Colonic Epithelium in Vivo*
Protein kinase C βII (PKCβII) is induced early during colon carcinogenesis. Transgenic mice expressing elevated PKCβII in the… 
2004
2004
A phase II trial of LY317615 in patients with recurrent high grade gliomas
1511 Background: Gliomas are amongst the most angiogenic of all solid tumors and experimental evidence suggests that angiogenesis… 
2002
2002
Targeted therapy using novel agents in the treatment of non-small-cell lung cancer.
Patients with advanced non-small-cell lung cancer (NSCLC) have a poor prognosis and high mortality. The therapeutic improvement… 
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