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Antitumor activity of Titanocene Y against freshly explanted human breast tumor cells and in xenografted MCF-7 tumors in mice
TLDR
The sensitivity against Titanocene Y was highly remarkable in the breast cancer tumor in the full concentration range, which resulted in the reduction of the tumor volume to around one-third, whereas no mouse was lost because of the surprisingly low toxicity of TitanoceneY.
In vitro chemosensitivity of freshly explanted tumor cells to pemetrexed is correlated with target gene expression
TLDR
Low levels of TS, GARFT, DHFR, and mrp4 gene expression significantly correlated with chemosensitivity to pemetrexed form a rational basis for the design of clinical trials to evaluate the expression of these enzymes as predictors for treatment outcome.
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in vitro soft-agar cloning experiments
TLDR
In addition to its established antiangiogenic effects, Enzastaurin has direct antitumor activity against established human cancer cell lines and primary tumor specimens, which warrants further clinical development in tumors which have been identified to be potentially sensitive to Enzastsaurin.
Antitumor activity of enzastaurin (LY317615.HCl) against human cancer cell lines and freshly explanted tumors investigated in in-vitro soft-agar cloning experiments
TLDR
In addition to its established antiangiogenic effects, Enzastaurin has direct antitumor activity against established human cancer cell lines and primary tumor specimens, which warrants further clinical development in tumors which have been identified to be potentially sensitive to Enzastsaurin.
Thymidylate synthase gene expression in solid tumors predicts for response to pemetrexed in vitro.
TLDR
TS expression is the most meaningful predictor for sensitivity or resistance to Pemetrexed in fresh tumor tissue, and forms a rationale for clinical trials using TS expression as predictor for clinical response.
Identification of a putative cation transporter gene from sugar beet (Beta vulgaris L.) by DDRT-PCR closely linked to the beet cyst nematode resistance gene Hs1pro-1
TLDR
A novel cDNA designated Bp23 was isolated from the translocation by comparing resistant and susceptible sugar beets of a segregating F2 population by differential display and shows similarity to Arabidopsis thaliana BAC clones and to diverse plant ESTs with similarity to the Escherichia coli cation transporter ChaC.
Optimization of Human NK Cell Manufacturing: Fully Automated Separation, Improved Ex Vivo Expansion Using IL-21 with Autologous Feeder Cells, and Generation of Anti-CD123-CAR-Expressing Effector
TLDR
A new NK cell expansion protocol was generated that resulted in high numbers of NK cells with potent antitumor activity, which could be modified efficiently by novel third-generation, alpha-retroviral SIN vector constructs.
Antiproliferative activity of Titanocene Y against tumor colony-forming units
TLDR
It is shown that the surprisingly good response of nonsmall cell lung cancer and colon cancer against Titanocene Y at its lowest concentration was well comparable or better with respect to cisplatin, given at a concentration of 1.0 μmol/l.
Redirected Primary Human Chimeric Antigen Receptor Natural Killer Cells As an “Off-the-Shelf Immunotherapy” for Improvement in Cancer Treatment
TLDR
This mini-review summarizes both the first preclinical trials with CAR-engineered primary human NK cells and the translational implications for “off-the-shelf immunotherapy” in cancer treatment.
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