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LY 544344

Known as: LY-544344, LY544344 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans
Group II metabotropic glutamate receptors (mGluR2/3) are suggested to modulate anxiety, arousal, and stress including autonomic… 
2010
2010
The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: in situ rat intestinal perfusion studies.
LY354740 is a potent mGlu2/3 agonist with a limited oral bioavailability. Its alanyl prodrug, LY544344, showed high affinity to… 
2009
2009
Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2…
The limited oral bioavailability of the potent and selective group II metabotropic glutamate (mGlu) 2/3 receptor agonist, (1S,2S… 
Highly Cited
2005
Highly Cited
2005
Effects of a metabotropic glutamate2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results
RationalePreclinical findings have repeatedly shown an anxiolytic-like action of agonists at metabotropic glutamate receptors… 
Review
2005
Review
2005
LY-544344. Eli Lilly.
  • W. Danysz
  • IDrugs : the investigational drugs journal
  • 2005
  • Corpus ID: 21820180
Eli Lilly and Co is developing LY-544344, a prodrug of the metabotropic glutamate receptor 2/3 agonist LY-354740, for the… 
2005
2005
Improved Bioavailability of the mGlu 2 / 3 Receptor Agonist LY 354740 Using a Prodrug Strategy : In Vivo Pharmacology of LY 544344
Numerous studies have indicated that selective agonists of group II metabotropic glutamate (mGlu) receptors, such as LY354740 and… 
2004
2004
Pharmacodynamics of a novel anxiolytic (LY544344)
2004
2004
Gateways to clinical trials.
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
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