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LY 544344
Known as:
LY-544344
, LY544344
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans
A. Agorastos
,
C. Demiralay
,
O. Stiedl
,
C. Muhtz
,
K. Wiedemann
,
M. Kellner
International Clinical Psychopharmacology
2016
Corpus ID: 13344426
Group II metabotropic glutamate receptors (mGluR2/3) are suggested to modulate anxiety, arousal, and stress including autonomic…
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Review
2012
Review
2012
New perspectives in glutamate and anxiety
C. R. Bermudo-Soriano
,
M. Perez-Rodriguez
,
C. Vaquero‐Lorenzo
,
E. Baca-García
Pharmacology, Biochemistry and Behavior
2012
Corpus ID: 22084226
Review
2010
Review
2010
Metabotropic Glutamate Receptors: Potential Drug Targets for Psychiatric Disorders
A. Yasuhara
,
S. Chaki
Open Medicinal Chemistry Journal
2010
Corpus ID: 7982464
Metabotropic glutamate receptors (mGlu receptors) have emerged as new therapeutic targets for psychiatric disorders, such as…
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2010
2010
The intestinal absorption of a prodrug of the mGlu2/3 receptor agonist LY354740 is mediated by PEPT1: in situ rat intestinal perfusion studies.
A. H. Eriksson
,
M. Varma
,
E. Perkins
,
C. Zimmerman
Journal of Pharmacy and Science
2010
Corpus ID: 24066741
LY354740 is a potent mGlu2/3 agonist with a limited oral bioavailability. Its alanyl prodrug, LY544344, showed high affinity to…
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2009
2009
Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2…
M. Varma
,
A. H. Eriksson
,
G. Sawada
,
Y. A. Pak
,
E. Perkins
,
C. Zimmerman
Drug Metabolism And Disposition
2009
Corpus ID: 206495616
The limited oral bioavailability of the potent and selective group II metabotropic glutamate (mGlu) 2/3 receptor agonist, (1S,2S…
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Highly Cited
2008
Highly Cited
2008
Efficacy and Tolerability of an mGlu2/3 Agonist in the Treatment of Generalized Anxiety Disorder
E. Dunayevich
,
J. Erickson
,
L. Levine
,
R. Landbloom
,
D. Schoepp
,
G. Tollefson
Neuropsychopharmacology
2008
Corpus ID: 20899635
LY354740, a potent and selective mGlu (metabotropic glutamate receptor)2/3 agonist, has shown efficacy in the treatment of…
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2007
2007
Pharmacokinetics, Metabolism, and Excretion of the Intestinal Peptide Transporter 1 (SLC15A1)-Targeted Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]aminobicyclo[3.1.0.]hexen-2,6-dicarboxylic…
E. Perkins
,
T. Abraham
Drug Metabolism And Disposition
2007
Corpus ID: 5639829
The peptidyl prodrug (1S,2S,5R,6S)-2-[(2′S)-(2-Amino)propionyl]a-minobicyclo[3.1.0.]hexen-2,6-dicarboxylic acid, also known as…
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Highly Cited
2006
Highly Cited
2006
Improved Bioavailability of the mGlu2/3 Receptor Agonist LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of LY544344
L. Rorick-Kehn
,
E. Perkins
,
+4 authors
D. McKinzie
Journal of Pharmacology and Experimental…
2006
Corpus ID: 1352829
Numerous studies have indicated that selective agonists of group II metabotropic glutamate (mGlu) receptors, such as LY354740…
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Highly Cited
2005
Highly Cited
2005
Effects of a metabotropic glutamate2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results
M. Kellner
,
C. Muhtz
,
K. Stark
,
A. Yassouridis
,
J. Arlt
,
K. Wiedemann
Psychopharmacology
2005
Corpus ID: 27965205
RationalePreclinical findings have repeatedly shown an anxiolytic-like action of agonists at metabotropic glutamate receptors…
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Review
2005
Review
2005
LY-544344. Eli Lilly.
W. Danysz
IDrugs : the investigational drugs journal
2005
Corpus ID: 21820180
Eli Lilly and Co is developing LY-544344, a prodrug of the metabotropic glutamate receptor 2/3 agonist LY-354740, for the…
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