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LY 411575

Known as: LY411,575, LY411575, LY-411,575 
National Institutes of Health

Papers overview

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2020
2020
Inhibition of the Notch1 pathway induces peripartum cardiomyopathy
Increased expression and activity of cardiac and circulating cathepsin D and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) have… 
2020
2020
Temporal Regulation of Notch Signaling and Its Influence on the Differentiation of Ex Vivo Cultured Limbal Epithelial Cells
ABSTRACT Purpose: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from… 
2019
2019
LY411575, a potent γ‐secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS‐induced calvarial osteolysis in vivo
A series of osteolytic bone diseases are usually related to excessive bone resorption and osteoclast formation. Thus, agents or… 
2012
2012
pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes.
Alzheimer's Disease implies memory and cognitive impairment due to beta amyloid accumulation, presence of reactive microglia and… 
2012
2012
Reducing Available Soluble &bgr;-Amyloid Prevents Progression of Cerebral Amyloid Angiopathy in Transgenic Mice
Abstract Cerebral amyloid angiopathy (CAA), the accumulation of &bgr;-amyloid (A&bgr;) in the walls of leptomeningeal and… 
2010
2010
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
BackgroundThe mutation in Huntington's disease is a polyglutamine expansion near the N-terminus of huntingtin. Huntingtin… 
2007
2007
Dominance of Amyloid Precursor Protein Sequence over Host Cell Secretases in Determining β-Amyloid Profiles Studies of Interspecies Variation and Drug Action by Internally Standardized…
β-Amyloid peptides, tentatively regarded as the principal neurotoxins responsible for Alzheimer's Disease, make up a set of… 
2007
2007
Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.
Structural modifications of the gamma-secretase inhibitor, LY411575, led to a malonamide analogue (S),(S)-1 with potent… 
2007
2007
A comparative analysis of brain and plasma Abeta levels in eight common non-transgenic mouse strains: validation of a specific immunoassay for total rodent Abeta.
Transgenic mouse models of Alzheimer's disease (AD) are being utilized as models for elucidating AD etiology and potential… 
2005
2005
JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia
found 17 mutations in 16 of 33 childhood T-ALL cases (48.5%), recapitulating the previous observation. It is intriguing to… 
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