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LY 411575

Known as: LY411,575, LY411575, LY-411,575 
National Institutes of Health

Papers overview

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2020
2020
Temporal Regulation of Notch Signaling and Its Influence on the Differentiation of Ex Vivo Cultured Limbal Epithelial Cells
ABSTRACT Purpose: Notch signaling plays a vital role in the differentiation and proliferation of corneal epithelial cells from… 
2016
2016
Notch signaling modulates proliferative vitreoretinopathy via regulating retinal pigment epithelial-to-mesenchymal transition
Elevated Notch signaling has been verified in a large range of fibrotic diseases developed in the kidney, liver, and lung… 
2015
2015
Hochentwickelte Aminopyrazol-Hybride gegen pathologische Prozesse der Alzheimer-Krankheit
Verschiedene Aminopyrazol-Trimer-Derivate wurden bereits in ihrer Aktivitat gegen die Aggregation des Abeta-Peptids untersucht… 
2010
2010
Synthesis of Key Intermediate of γ-Secretase Inhibitor LY411575
Objective To synthesize the key intermediate(S)-5-methyl-7-amino-5H,7H-dibenzo[b,d]azepin-6-one(1A)of γ-secretase inhibitor… 
2007
2007
Novel orally active, dibenzazepinone-based gamma-secretase inhibitors.
Structural modifications of the gamma-secretase inhibitor, LY411575, led to a malonamide analogue (S),(S)-1 with potent… 
2005
2005
JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia
found 17 mutations in 16 of 33 childhood T-ALL cases (48.5%), recapitulating the previous observation. It is intriguing to… 
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