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LY 309887

Known as: LY309887 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
In human methylenetetrahydrofolate reductase (MTHFR) the Ala222Val (677C-->T) polymorphism encodes a heat-labile gene product… 
Review
2003
Review
2003
Antimetabolites are active chemotherapeutic agents for many solid tumor and hematologic malignancies. Folate antagonists, purine… 
2003
2003
A flexible approach to response surface modeling for the study of the joint action of three active anticancer agents is used to… 
Highly Cited
2000
Highly Cited
2000
The scheduling of antifolate antitumor agents, including the new multitargeted autofolate LY231514 (MTA), with 5-fluorouracil was… 
2000
2000
The antifolate LY309887 is a specific glycinamide ribonucleotide formyltransferase inhibitor that blocks de novo purine synthesis… 
Highly Cited
1999
Highly Cited
1999
Prior studies have indicated that MTA requires intracellular polyglutamation for optimal cytotoxic effect and that these… 
Review
1998
Review
1998
  • S. Kaye
  • British Journal of Cancer
  • 1998
  • Corpus ID: 6066461
It is almost 50 years since antimetabolites were first found to have clinical antitumour activity, with Farber's discovery that… 
Highly Cited
1997
Highly Cited
1997
Abstract Purpose: Cell cycle-related events in CCRF-CEM lymphocytic leukemia cells were examined subsequent to inhibition of…