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LY 309887

Known as: LY309887 
National Institutes of Health

Papers overview

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2006
2006
Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
2006
2006
The Critical Role of Polyglutamylation Reductase and Inhibitors of Other Folate-requiring Enzymes : Synergy between Inhibitors of Dihydrofolate in Vitro Super Updated
The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reducÃ-ase… 
2004
2004
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol
SummaryLometrexol, a tight-binding antifolate inhibitor of the purine de novo enzyme glycinamide ribonucleotide formyltransferase… 
2004
2004
Epilogue
The last time I saw Jerry Grindey, it was early in the 84th Annual Meeting of the American Association for Cancer Research. We… 
2003
2003
LY 309887 , antifolate via the folate receptor suppresses murine type II collagen-induced arthritis
Objective To examine the effect of LY309887, an inhibitor of glycinamide ribonucleotide formyltransferase in de novo purine… 
2001
2001
Phase I and pharmacokinetic study of LY309887: a specific inhibitor of purine biosynthesis
Abstract. Purpose: In this phase I trial in humans the safety and pharmacology of LY309887 on a weekly schedule combined with… 
Review
1999
Review
1999
Preclinical and Clinical Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitors Lometrexol and LY309887
The importance of the purine de novo pathway in providing DNA precursors for cancer cell growth led to the hypothesis that novel… 
1999
1999
Cellular pharmacology of MTA: a correlation of MTA-induced cellular toxicity and in vitro enzyme inhibition with its effect on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells…
The mechanism of action of an antifolate may be investigated using a variety of experimental methods. These include experiments… 
1998
1998
A sensitive and specific radioimmunoassay for LY309887, a potent inhibitor of glycinamide ribonucleotide formyltransferase.
LY309887, a reduced analogue of folic acid, is a potent inhibitor of glycinamide ribonucleotide formyltransferase and possesses a… 
1997
1997
Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet
Purpose: The whole-body autoradiographic distribution of two radiolabeled antifolate inhibitors of GAR formyltransferase… 
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