LY 309887

Known as: LY309887 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2015
024619962015

Papers overview

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2006
2006
In human methylenetetrahydrofolate reductase (MTHFR) the Ala222Val (677C-->T) polymorphism encodes a heat-labile gene product… (More)
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2003
2003
A flexible approach to response surface modeling for the study of the joint action of three active anticancer agents is used to… (More)
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2001
2001
Folates have been co-administered with some antifolates to diminish host toxicity; however, the extent to which this will reduce… (More)
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2000
2000
The scheduling of antifolate antitumor agents, including the new multitargeted autofolate LY231514 (MTA), with 5-fluorouracil was… (More)
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2000
2000
The antifolate LY309887 is a specific glycinamide ribonucleotide formyltransferase inhibitor that blocks de novo purine synthesis… (More)
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1999
1999
Prior studies have indicated that MTA requires intracellular polyglutamation for optimal cytotoxic effect and that these… (More)
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Highly Cited
1998
Highly Cited
1998
Extensive biochemical and pharmacological evidence indicates that LY231514 is a novel antifolate antimetabolite. LY231514 is… (More)
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1998
1998
The combined action among polyglutamylatable and nonpolyglutamylatable antifolates, directed against dihydrofolate reductase… (More)
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1998
1998
LY231514 (N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethy l]-benzoyl]-L-glutamic acid) is a new folate… (More)
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1997
1997
 Purpose: Cell cycle-related events in CCRF-CEM lymphocytic leukemia cells were examined subsequent to inhibition of thymidylate… (More)
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