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LY 2275796

Known as: LY2275796, eIF4E Antisense Oligonucleotide ISIS 183750, eIF4E Modulator ISIS 183750 
A second-generation antisense oligonucleotide targeting the eukaryotic translation initiation factor 4E (eIF4E) with potential antitumor activity… 
National Institutes of Health

Related topics

Related topics

2 relations
NCIt Antineoplastic Agent Terminology

Broader (1)

Oligonucleotides

Papers overview

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2015
2015
ISIS-ANGPTL3RX, an antisense inhibitor to angiopoietin-like 3, reduces plasma lipid levels in mouse models and in healthy human volunteers
2013
2013
Results of an Open-Label, Escalating Dose Study To Assess the Safety, Tolerability, and Dose Range Finding of a Single Intrathecal Dose of ISIS-SMN Rx in Patients with Spinal Muscular Atrophy (S36…
OBJECTIVE: This first-in-human study was conducted to evaluate the safety, tolerability, and pharmacokinetics of escalating… 
2013
2013
Motoneuron double discharges: only one or two different entities?
The firing behavior of spinal motoneurons is controlled by a complex interplay between the synaptic inputs that they receive and… 
2011
2011
Four new polyoxygenated gorgosterols from the gorgonian Isis hippuris
Four new polyoxygenated steroids (1–4) together with four known ones (5–8) have been isolated from the gorgonian Isis hippuris… 
2010
2010
Berenike: archaeological fieldwork at a Ptolemaic-Roman port on the Red Sea coast of Egypt 2011-2012
Des recherches de terrain ont complete nos connaissances sur les contacts de Berenice avec la mer Rouge et l'Ocean Indien, y… 
Highly Cited
2008
Highly Cited
2008
ISIS-DME: A Prospective, Randomized, Dose-Escalation Intravitreal Steroid Injection Study for Refractory Diabetic Macular Edema
Purpose: To determine safety and efficacy of intravitreal triamcinolone acetonide (IVTA) for refractory clinically significant… 
2003
2003
Sesamia calamistis Calling Behavior and Its Role in Host Finding of Egg Parasitoids Telenomus busseolae, Telenomus isis, and Lathromeris ovicida
In the Republic of Benin, the African pink stem borer Sesamiacalamistis Hampson is kept under control by the two scelionid egg… 
2001
2001
Two new polyhydroxysteroids from the gorgonian Isis hippuris
2000
2000
Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells
Reactive oxygen species (ROS) are implicated in the pathogenesis of several proliferative diseases, including atherosclerosis and… 
2000
2000
New triterpenoid saponins from the sponge Melophlus isis.
Four new triterpenoid saponins were isolated, along with two known 30-norlanostane-type saponins- sarasinosides A(1) (1) and A(3… 
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