Anticholinesterase activity of plastoquinones from Sargassum sagamianum: lead compounds for alzheimer's disease therapy
- B. Choi, G. Ryu, Bong-Ho Lee
- Chemistry, BiologyPhytotherapy Research
- 1 May 2007
During the search for anticholinesterase compounds from marine organisms, two known plastoquinones, sargaquinoic acid and sargachromenol, were isolated from Sargassum sagamianum and showed particularly potent inhibitory activity, making them an interesting potential drug candidate for Alzheimer's disease.
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
- J. Koo, Yongwoo Jang, U. Oh
- BiologyEuropean Journal of Neuroscience
- 2007
It is concluded that the activations of TRPV1 and TRPA1 by HalphaSS explain its unique pungent, tingling sensation.
Ohmyungsamycins A and B: cytotoxic and antimicrobial cyclic peptides produced by Streptomyces sp. from a volcanic island.
- S. Um, T. J. Choi, D. Oh
- ChemistryJournal of Organic Chemistry
- 26 November 2013
A new method utilizing PGME (phenylglycine methyl ester) derivatization coupled with chromatographic analysis to determine the absolute configuration of N,N-dimethylvaline is developed, which will provide a general and convenient analytical method for determining the absolute configurations of amino acids with fully substituted amine groups.
Kurarinone regulates immune responses through regulation of the JAK/STAT and TCR-mediated signaling pathways.
- Byung-Hak Kim, Kwang-Min Na, Tae-Yoon Kim
- BiologyBiochemical Pharmacology
- 15 April 2013
Chromenes from the brown alga Sargassum siliquastrum.
- K. Jang, Bong-Ho Lee, B. Choi, Hyi-Seung Lee, Jongheon Shin
- ChemistryJournal of Natural Products
- 27 April 2005
Sargachromanols A-P (1-16), sixteen new meroterpenoids of the chromene class, were isolated from the brown alga Sargassum siliquastrum collected from Jaeju Island, Korea and exhibited significant antioxidant activity in the DPPH assay.
Meroditerpenoids from the brown alga Sargassum siliquastrum.
- Mi-Kyoung Jung, K. Jang, Jongheon Shin
- ChemistryJournal of Natural Products
- 26 September 2008
Eleven new meroditerpenoids (7-11, 14-17, 19, 20) and nine known compounds (1-6, 12, 13, 18) were isolated from the brown alga Sargassum siliquastrum and a common tetraprenyl hydroquinone structure was revealed.
Pentacyclic antibiotics from a tidal mud flat-derived actinomycete.
Buanmycin exhibited potent cytotoxicity against colorectal carcinomas cells and gastric carcinoma cells and strongly inhibited the pathogenic Gram-negative bacterium Salmonella enterica and demonstrated inhibition of sortase A, which is a promising target for antibiotic discovery.
Hydroxy‐α‐sanshool activates TRPV1 and TRPA1 in sensory neurons
- J. Koo, Yongwoo Jang, U. Oh
- Biology
- 1 September 2007
It is concluded that the activations of TRPV1 and TRPA1 by HαSS explain its unique pungent, tingling sensation.
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
- T. H. Won, Inn-Hye Song, Jongheon Shin
- Chemistry, MedicineJournal of Natural Products
- 24 February 2015
Twenty-four metabolites, including seven new compounds (1-7), were isolated from the dried fruits of Psoralea corylifolia and were determined to be six flavonoids and a meroterpenoid.
Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera.
- Hyi-Seung Lee, Taehun Lee, K. Oh
- BiologyJournal of Agricultural and Food Chemistry
- 26 July 2007
The protective effect of bromophenols and their strong inhibition of appressorium formation on rice plants suggest that ICL inhibitors may be promising candidates for crop protection, particularly to protect rice plants against M. grisea.
...
...