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Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
It is concluded that the activations of TRPV1 and TRPA1 by HalphaSS explain its unique pungent, tingling sensation. Expand
Anticholinesterase activity of plastoquinones from Sargassum sagamianum: lead compounds for alzheimer's disease therapy
During the search for anticholinesterase compounds from marine organisms, two known plastoquinones, sargaquinoic acid and sargachromenol, were isolated from Sargassum sagamianum and showed particularly potent inhibitory activity, making them an interesting potential drug candidate for Alzheimer's disease. Expand
Hydroxy‐α‐sanshool activates TRPV1 and TRPA1 in sensory neurons
Sanshools are major active ingredients of Zanthoxylum piperitum and are used as food additives in East Asia. Sanshools cause irritant, tingling and sometimes paresthetic sensations on the tongue.Expand
Chromenes from the brown alga Sargassum siliquastrum.
Sargachromanols A-P (1-16), sixteen new meroterpenoids of the chromene class, were isolated from the brown alga Sargassum siliquastrum collected from Jaeju Island, Korea and exhibited significant antioxidant activity in the DPPH assay. Expand
Sungsanpin, a lasso peptide from a deep-sea streptomycete.
Sungsanpin is the first example of a lasso peptide isolated from a marine-derived microorganism and displayed inhibitory activity in a cell invasion assay with the human lung cancer cell line A549. Expand
The junceellolides, new anti-inflammatory diterpenoids of the briarane class from the chinese gorgonian junceella fragilis
Abstract Four new diterpenoids, junceellolides A-D (1-4), have been isolated from the gorgonian Junceella fragilis collected in the South China Sea. The known metabolites praelolide (5) andExpand
Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera.
The protective effect of bromophenols and their strong inhibition of appressorium formation on rice plants suggest that ICL inhibitors may be promising candidates for crop protection, particularly to protect rice plants against M. grisea. Expand
Psammaplin A is a natural prodrug that inhibits class I histone deacetylase
It is demonstrated that Psam A could exhibit its activity under the reduced condition in the cells and be a new natural prodrug targeting HDAC. Expand
Kurarinone regulates immune responses through regulation of the JAK/STAT and TCR-mediated signaling pathways.
This study provides new evidence that kurarinone may ameliorate chronic inflammatory skin diseases through the suppression of pathogenic CD4(+) T-cell differentiation and the overall immune response. Expand