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LOXL2 gene

Known as: lysyl oxidase like 2, WS9-14, LYSYL OXIDASE-LIKE 2 
This gene is involved in protein crosslinking.
National Institutes of Health

Related topics

Related topics

6 relations
AgingCell AdhesionLysyl Oxidase Homolog 2Oxidation-Reduction

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LOXL2 wt Allele

Papers overview

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Highly Cited
2020
Highly Cited
2020
Wnt signaling and Loxl2 promote aggressive osteosarcoma
Osteosarcoma (OS) is the most frequent primary malignant bone tumor in urgent need of better therapies. Using genetically… 
Highly Cited
2017
Highly Cited
2017
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
Background/Aims We studied the role of lysyl oxidase-like 2 (LOXL2) in collagen crosslinking and hepatic progenitor cell (HPC… 
Highly Cited
2016
Highly Cited
2016
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
Interstitial fibrosis plays a key role in the development and progression of heart failure. Here, we show that an enzyme that… 
Highly Cited
2015
Highly Cited
2015
LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival
Purpose: Cancer-associated fibroblasts (CAF) are major mediators in tumor microenvironment. We investigated the changes in… 
Highly Cited
2014
Highly Cited
2014
Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization
Epithelial–mesenchymal transition (EMT) has been associated with increased aggressiveness and acquisition of migratory properties… 
Highly Cited
2013
Highly Cited
2013
Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition.
Highly Cited
2010
Highly Cited
2010
The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin
The lysyl oxidase-like 2 (LOXL2) protein is a human paralogue of lysyl oxidase (LOX) that functions as an amine oxidase for… 
Highly Cited
2008
Highly Cited
2008
Decreased endopelvic fascia elastin content in uterine prolapse
Background. Genital prolapse is a debilitating manifestation of pelvic floor dysfunction. The cause of this condition has not… 
Highly Cited
1999
Highly Cited
1999
The LOXL2 Gene Encodes a New Lysyl Oxidase-like Protein and Is Expressed at High Levels in Reproductive Tissues*
We have reported in this paper the complete cDNA sequence, gene structure, and tissue-specific expression of LOXL2, a new amine… 
Highly Cited
1997
Highly Cited
1997
Regulation of a Novel Gene Encoding a Lysyl Oxidase-related Protein in Cellular Adhesion and Senescence*
We report here a novel cDNA clone with a predicted protein sequence similar to lysyl oxidase. This full-length cDNA clone of 3432… 
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