FAQ

LNP 509

Known as: dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)amine, lnp-509 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2017
0120012017

Related topics

Related topics

2 relations

Broader (2)

CyclopropanesPyrroles

Related mentions per year

Related mentions per year

1939-2018
19401960198020002020
LNP 509
Pyrroles
Cyclopropanes

Papers overview

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2017
2017
Preclinical Pharmacology and Pharmacokinetics of Inhaled Hexadecyl-Treprostinil (C16TR), a Pulmonary Vasodilator Prodrug.
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of… (More)
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2015
2015
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade… (More)
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2006
2006
Opposite to alpha2-adrenergic agonists, an imidazoline I1 selective compound does not influence reflex bradycardia in rabbits.
This work aimed to study the respective effects of central alpha2-adrenergic receptors (alpha2-ARS) and I1 imidazoline receptors… (More)
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2002
2002
Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation.
BACKGROUND Both alpha(2)-adrenergic and non--alpha(2)-adrenergic mechanisms seem to be involved in the hypotensive effect of… (More)
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2002
2002
Evidence for Synergy Between 2-Adrenergic and Nonadrenergic Mechanisms in Central Blood Pressure Regulation
Background—Both 2-adrenergic and non– 2-adrenergic mechanisms seem to be involved in the hypotensive effect of imidazoline-like… (More)
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2001
2001
Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline…
To find new compounds selective for purported I1 imidazoline receptors (I1Rs) over I2 imidazoline binding sites (I2BS) and alpha2… (More)
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