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LND 623

Known as: LND-623, alpha-L-Mannopyranoside, (3beta,5beta,14beta,20R)-14-amino-20-hydroxypregnan-3-yl 6-deoxy- 
National Institutes of Health

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2 relations

Broader (2)

MannosidesPregnanes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Mechanism Underlying the Strong Positive Inotropic Effects of LND-623: Specific Inhibition of Na, K-ATPase Isoforms and Exclusion of Cellular Sites of Contractile Control
LND-623 is a new aminosteroid analog of ouabain, with a greater separation between efficacy and toxicity than ouabain. To… 
1992
1992
Digitaloid pregnanes promote potassium-sparing diuresis in the guinea pig.
The synthesis of 17 alpha-acetoxy-3 beta-[(beta-D-glucopyranosyl)oxy]- 6 alpha-methylpregn-4-en-20-one, the glucoside of… 
1992
1992
Efficacy and safety of the novel Na+,K(+)-ATPase inhibitor 20R 14 beta-amino 3 beta-rhamnosyl 5 beta-pregnan 20 beta-ol in a dog model of heart failure.
20R 14 beta-amino 3 beta-rhamnosyl 5 beta-pregnan 20 beta-ol (LND 623, CAS 90520-42-6) was investigated and compared to digoxin… 
1990
1990
POSITIVE INOTROPIC AND VASOCONSTRICTOR RESPONSES TO 14β‐AMINOPREGNANE DERIVATIVES IN ISOLATED TISSUES FROM THE GUINEA‐PIG
1. The objective of this study was to compare the positive inotropic and vasoconstrictor responses in guinea‐pig isolated tissues… 
1989
1989
COMPARATIVE HEMODYNAMIC STUDY OF A NEW AMINOSTEROID: LND‐623 WITH ITS 20α‐ISOMER: LND‐369, AND WITH DIGOXIN AND DIGOXIGENIN‐RHAMNOSIDE IN THE ANESTHETIZED DOG
Summary— Hemodynamic effects of LND‐623, a new aminosteroid lacking the C17 lactone ring and the C14 hydroxyl group common to the… 
1988
1988
Electrical and mechanical effects of new aminosteroids on guinea‐pig isolated ventricular muscle
1 LND 623 and LND 796 are two aminosteroid derivatives which exert similar positive inotropic effects to digitalis. Their… 
1984
1984
A new inotropic aminosteroid: LND 623.
It is usually postulated that the side chain attached to 17 beta position on the steroid nucleus of the cardioactive glycosides… 
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