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LLC-PK1 Cells

Known as: Cell, LLC-PK1, LLC-PK1 Cell, LLC PK1 Cells 
Epithelial cell line originally derived from porcine kidneys. It is used for pharmacologic and metabolic studies.
National Institutes of Health

Related topics

Related topics

6 relations
CellularMicrobiologicalProcess of secretionaspects of radiation effects

Broader (1)

Cultured Cell Line

Papers overview

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Highly Cited
2007
Highly Cited
2007
Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging.
Hypertensive patients exhibit elevated cancer incidence, especially of cancers of the kidney. Elevated levels of ANG II, the… 
2004
2004
Evaluation of long-term transport ability of a bioartificial renal tubule device using LLC-PK1 cells.
BACKGROUND Haemodialysis therapy does not provide renal tubule function, such as active fluid and solute transport, nor metabolic… 
Highly Cited
1998
Highly Cited
1998
Cadmium is more toxic to LLC-PK1 cells than to MDCK cells acting on the cadherin-catenin complex.
Cadmium toxicity to renal cells was investigated in Madin-Darby canine kidney (MDCK) and LLC-PK1 cells as models of the distal… 
Highly Cited
1998
Highly Cited
1998
Overexpression of protein kinase C-δ increases tight junction permeability in LLC-PK1epithelia.
The Ca2+-independent δ-isoform of protein kinase C (PKC-δ) was overexpressed in LLC-PK1 epithelia and placed under control of a… 
Highly Cited
1996
Highly Cited
1996
Angiotensin II-stimulated hypertrophy of LLC-PK1 cells depends on the induction of the cyclin-dependent kinase inhibitor p27Kip1.
Angiotensin II (Ang II) induces hypertrophy of cultured proximal tubular epithelial cells including the LLC-PK1 cell line. We… 
1996
1996
Response of LLC-PK1-F+ cells to metabolic acidosis.
The role of extracellular glutamate formation as opposed to cellular glutamate removal in regulating monolayer glutamate content… 
Highly Cited
1994
Highly Cited
1994
Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells.
Porcine kidney tubular epithelial cells (LLC-PK1) produce nitric oxide or a related compound (e.g., a nitrosothiol) after… 
Highly Cited
1994
Highly Cited
1994
Effect of high osmolality on Na+/H+ exchange in renal proximal tubule cells.
Highly Cited
1991
Highly Cited
1991
Hydrogen peroxide cytotoxicity in LLC-PK1 cells: a role for iron.
Reactive oxygen metabolites have been postulated to play an important role in both toxic and ischemic forms of acute renal… 
Highly Cited
1988
Highly Cited
1988
Pharmacologically different Na/H antiporters on the apical and basolateral surfaces of cultured porcine kidney cells (LLC-PK1).
Proximal tubule cells of the kidney contain, on their apical surface, an amiloride-sensitive Na/H antiporter that functions in Na… 
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