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Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.
TLDR
Three isozymes of nitric oxide (NO) synthase (EC 1.14.39) have been identified and the cDNAs for these enzymes isolated and there is no evidence for more than one inducible isozyme at this time. Expand
A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects.
TLDR
AL-438 is described, a GR ligand that exhibits an altered gene regulation profile, able to repress and activate only a subset of the genes normally regulated by GCs, and serves as a prototype for a unique, nonsteroidal alternative to conventional GCs in treating inflammatory disease. Expand
Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal
TLDR
The findings suggest that NOS-I is the most widely distributed isoform of NOS and, in addition to its neural functions, regulates secretion and non-vascular smooth muscle function. Expand
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
TLDR
The particulate enzyme responsible for the synthesis of endothelium-derived relaxing factor has been purified from cultured and native (noncultured) bovine aortic endothelial cells and required L-arginine, NADPH, Ca2+, calmodulin, and 5,6,7,8-tetrahydrobiopterin for full activity. Expand
Neurons in rat cerebral cortex that synthesize nitric oxide: NADPH diaphorase histochemistry, NOS immunocytochemistry, and colocalization with GABA
TLDR
Neurons that stain for NADPH diaphorase, which colocalizes with nitric oxide synthase (NOS), are scattered uniformly across neocortex, and denser in entorhinal cortex, whereas NOS-positive fibers are concentrated in layers IV and VI. Expand
Novel potent and selective inhibitors of inducible nitric oxide synthase.
TLDR
Two novel potent and selective inhibitors of inducible nitric oxide synthase, S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine, are identified and may have potential therapeutic applications in the treatment of inflammatory and autoimmune diseases. Expand
A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative
TLDR
It is suggested that during fixation most NADPH-diaphorase activity is inactivated and only some of the NAD PH- diaphorases activity associated with soluble nitric oxide synthase remains intact. Expand
Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
TLDR
Unexpectedly, messenger RNA levels of this isoform of NO synthase was more abundant in human skeletal muscle than human brain, indicating a possible novel function of NO in skeletal muscle. Expand
Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase.
TLDR
Findings indicate that brain nitric oxide synthase activity may be regulated not only by Ca2+/calmodulin and several co-factors, but also by phosphorylation. Expand
Neurons in rat hippocampus that synthesize nitric oxide
TLDR
Double staining experiments demonstrated that nearly all NADPH diaphorase‐positive neurons in the hippocampus also contained γ‐aminobutyric acid. Expand
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