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LIG4 gene

Known as: DNA joinase, DNA repair enzyme, LIG4 
This gene plays a critical role in the regulation of nonhomologous DNA end joining and in V(D)J recombination.
National Institutes of Health

Related topics

Related topics

10 relations
DNA LigasesDNA RepairDNA Repair EnzymesDNA ligase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Azoospermic infertility is associated with altered expression of DNA repair genes.
2015
2015
Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency.
2015
2015
Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.
2014
2014
Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity
Background and purposeThe aim of this study was to determine the impact of functional single nucleotide polymorphism (SNP… 
2013
2013
Ku80-deleted cells are defective at base excision repair.
Highly Cited
2007
Highly Cited
2007
Low levels of DNA ligases III and IV sufficient for effective NHEJ
Cells of higher eukaryotes rejoin double strand breaks (DSBs) in their DNA predominantly by a non‐homologous DNA end joining… 
2001
2001
Phenotypic Analysis and Virulence of Candida albicans LIG4 Mutants
ABSTRACT In previous studies, we reported the isolation and preliminary characterization of a DNA ligase-encoding gene of Candida… 
1999
1999
Baby, don't stop!
Review
1997
Review
1997
Mammalian DNA ligases
DNA joining enzymes play an essential role in the maintenance of genomic integrity and stability. Three mammalian genes encoding… 
Highly Cited
1967
Highly Cited
1967
The enzymatic repair of DNA, II. Characterization of phage-induced sealase.
This purification procedure has also been used with extracts prepared from T7-infected E. coli B with similar results. 
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