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LGR5 gene

Known as: LGR5, Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Gene, GPR49 
This gene plays a role in receptor-mediated signaling.
National Institutes of Health

Related topics

Related topics

7 relations
G Protein-Coupled Receptor SignalingLGR5 protein, humanLeucine-Rich Repeat-Containing G-Protein Coupled Receptor 5Ligand Binding

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LGR5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem cell self-renewal
The canonical Wnt/β-catenin signalling pathway governs diverse developmental, homeostatic and pathological processes… 
Review
2014
Review
2014
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
Adult stem cells are controlled by an intricate interplay of potent Wnt agonists, antagonists, and anti-antagonists. This review… 
Highly Cited
2013
Highly Cited
2013
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt… 
Highly Cited
2011
Highly Cited
2011
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
The Wnt/β-catenin signaling system plays essential roles in embryonic development and in the self-renewal and maintenance of… 
Highly Cited
2011
Highly Cited
2011
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
Highly Cited
2011
Highly Cited
2011
LGR4 and LGR5 are R‐spondin receptors mediating Wnt/β‐catenin and Wnt/PCP signalling
R‐spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose… 
Highly Cited
2011
Highly Cited
2011
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
We report that breast cancer cells that infiltrate the lungs support their own metastasis-initiating ability by expressing… 
Highly Cited
2009
Highly Cited
2009
Crypt stem cells as the cells-of-origin of intestinal cancer
Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most… 
Highly Cited
2007
Highly Cited
2007
Identification of stem cells in small intestine and colon by marker gene Lgr5
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six… 
Highly Cited
2007
Highly Cited
2007
Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry
Hepatocellular adenomas (HCA) with activated β‐catenin present a high risk of malignant transformation. To permit robust routine… 
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