LGR5 gene

Known as: LGR5, Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Gene, GPR49 
This gene plays a role in receptor-mediated signaling.
National Institutes of Health

Papers overview

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Review
2014
Review
2014
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently… (More)
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Highly Cited
2014
Highly Cited
2014
Like normal colorectal epithelium, colorectal carcinomas (CRCs) are organized hierarchically and include populations of cells… (More)
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Highly Cited
2013
Highly Cited
2013
The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled receptor 5) marks actively dividing stem cells in Wnt… (More)
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Highly Cited
2011
Highly Cited
2011
The Wnt/β-catenin signaling system plays essential roles in embryonic development and in the self-renewal and maintenance of… (More)
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Highly Cited
2011
Highly Cited
2011
R-spondins are secreted Wnt signalling agonists, which regulate embryonic patterning and stem cell proliferation, but whose… (More)
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Highly Cited
2011
Highly Cited
2011
We report that breast cancer cells that infiltrate the lungs support their own metastasis-initiating ability by expressing… (More)
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Highly Cited
2011
Highly Cited
2011
Gene signatures derived from cancer stem cells (CSCs) predict tumor recurrence for many forms of cancer. Here, we derived a gene… (More)
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Highly Cited
2009
Highly Cited
2009
Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most… (More)
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Highly Cited
2009
Highly Cited
2009
The orphan Leucine-rich repeat G protein-coupled receptor 5 (LGR5/GPR49), a target of Wnt signaling, is a marker of adult… (More)
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Highly Cited
2007
Highly Cited
2007
The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently believed that four to six… (More)
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