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LGR5 gene

Known as: LGR5, Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Gene, GPR49 
This gene plays a role in receptor-mediated signaling.
National Institutes of Health

Related topics

Related topics

7 relations
G Protein-Coupled Receptor SignalingLGR5 protein, humanLeucine-Rich Repeat-Containing G-Protein Coupled Receptor 5Ligand Binding

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LGR5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract 32: Preclinical evaluation of MCLA-158: A bispecific antibody targeting LGR5 and EGFR using patient-derived colon carcinoma organoids
Background. Colorectal cancer (CRC) is the third most common cancer and remains a large unmet need. Dysregulation of Wnt and… 
Review
2017
Review
2017
Novel Insights into Gastric Cancer : Methylation of R-spondins and Regulation of LGR 5 by SP 1
Recently, it was shown that leucine-rich repeat-containing receptor 5 (LGR5)–expressing stem cells are the cellular origin of… 
2016
2016
336 Small RNA Sequencing of Glioblastoma Multiforme Extracellular Vesicles.
INTRODUCTION Glioblastoma (GBM) subverts the immune system toward immunosuppression through transfer of oncogenic components… 
2016
2016
Rspo1/LGR5 pathway promotes cervical cancer cell growth and is correlated with the high pathological grade
Objective: To investigate the significance of LGR5 expression on cervical cancer and to explore the role of Rspo1/LGR5 pathway in… 
Review
2016
Review
2016
Impact of LGR 5 in colorectal cancer on overall and progression-free survival : a systematic review and meta-analysis
Objective: The prognostic and clinical significance of LGR5 in Colorectal Cancer (CRC) remains controversial. Here, we conducted… 
2015
2015
Abstract 2639: Preclinical evaluation and biomarker identification for the anti-LGR5 mAb BNC101 in K-Ras mutant CRC and other solid tumor indications
2014
2014
LGR 5 expression in oral epithelial dysplasia and oral squamous cell carcinoma
144 words. Manuscript: 1472 words, including figure legends. No tables, Two colour figures. One supplementary element (positive… 
2013
2013
Significance of Stem Cell Marker Lgr5 Expression in Colorectal Carcinogenesis
Background: Lgr5 (Leucine rich repeat containing Gprotein-coupled receptors) also known as G-protein-coupled receptor (Gpr-49… 
2012
2012
Stem cells: Marking stem cells
A paper inCellidentifies a subpopulation of intestinal stem cells that are characterized by the expression of LRIG1, which the… 
1982
1982
Another gene affecting sexual expression of Escherichia coli
We have examined the relationship between two chromosomal mutations of Escherichia coli K-12, fexA (0 min) and fexB (85 min), in… 
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