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LGR5 gene

Known as: LGR5, Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5 Gene, GPR49 
This gene plays a role in receptor-mediated signaling.
National Institutes of Health

Related topics

Related topics

7 relations
G Protein-Coupled Receptor SignalingLGR5 protein, humanLeucine-Rich Repeat-Containing G-Protein Coupled Receptor 5Ligand Binding

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LGR5 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
RSPO2 enhances cell invasion and migration via the WNT/β‐catenin pathway in human gastric cancer
R‐spondins comprise a group of secreted WNT agonists. R‐spondin2 (RSPO2) plays a crucial role in the activation of the WNT… 
2017
2017
An miRNA Expression Signature for the Human Colonic Stem Cell Niche Distinguishes Malignant from Normal Epithelia.
Malignant transformation of tissue stem cells (SC) may be the root of most cancer. Accordingly, we identified miRNA expression… 
2017
2017
FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells.
Review
2017
Review
2017
Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1
Recently, it was shown that leucine-rich repeat-containing receptor 5 (LGR5)–expressing stem cells are the cellular origin of… 
2016
2016
Stem Cell-Associated Marker Expression in Canine Hair Follicles
Functional hair follicle (HF) stem cells (SCs) are crucial to maintain the constant recurring growth of hair. In mice and humans… 
2016
2016
Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt.
2015
2015
Development of intestinal organoids as tissue surrogates: Cell composition and the Epigenetic control of differentiation
Intestinal organoids are multicellular crypt‐like structures that can be derived from adult intestinal stem cells (ISCs… 
2015
2015
SOX9-mediated upregulation of LGR5 is important for glioblastoma tumorigenicity.
2011
2011
Dissecting cancer heterogeneity
Transcriptional profiling of single cells in colon tumors may enable prediction of patient outcomes. 
2008
2008
A role for GATA-6 in vertebrate chondrogenesis.
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