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LGK974

Known as: PORCN inhibitor LGK974 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… 
Highly Cited
2017
Highly Cited
2017
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein… 
Highly Cited
2017
Highly Cited
2017
Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted… 
Highly Cited
2016
Highly Cited
2016
The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9 is implicated in prostate cancer… 
2015
2015
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted… 
Highly Cited
2015
Highly Cited
2015
Abstract Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using… 
Highly Cited
2013
Highly Cited
2013
Significance Targeting the Wnt pathway in cancer is an attractive therapeutic approach. However, success has been limited because… 
Highly Cited
2013
Highly Cited
2013
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However…