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LGK974

Known as: PORCN inhibitor LGK974 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
&NA; Activation of the Wnt signaling pathway promotes lung cancer progression and contributes to poor patient prognosis. The… Expand
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2017
2017
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein… Expand
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Review
2017
Review
2017
Wnt/β‐catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… Expand
Highly Cited
2017
Highly Cited
2017
Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted… Expand
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2017
2017
In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However… Expand
Highly Cited
2016
Highly Cited
2016
The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9 is implicated in prostate cancer… Expand
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2015
2015
Abstract Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using… Expand
2015
2015
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted… Expand
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Highly Cited
2013
Highly Cited
2013
  • J. Liu, S. Pan, +33 authors J. Harris
  • Proceedings of the National Academy of Sciences
  • 2013
  • Corpus ID: 24680385
Significance Targeting the Wnt pathway in cancer is an attractive therapeutic approach. However, success has been limited because… Expand
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Highly Cited
2013
Highly Cited
2013
  • Xiaomo Jiang, Huai-Xiang Hao, +16 authors Feng Cong
  • Proceedings of the National Academy of Sciences
  • 2013
  • Corpus ID: 205263798
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However… Expand
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