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LGK974

Known as: PORCN inhibitor LGK974 
 
National Institutes of Health

Papers overview

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2018
2018
&NA; Activation of the Wnt signaling pathway promotes lung cancer progression and contributes to poor patient prognosis. The… Expand
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Review
2017
Review
2017
Canonical WNT signaling through Frizzled and LRP5/6 receptors is transduced to the WNT/β-catenin and WNT/stabilization of… Expand
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Review
2017
Review
2017
Wnt/β-catenin pathway is one of the main/frequent dysregulated pathways in several tumor types, including colon cancer. Aberrant… Expand
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2017
2017
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein… Expand
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2017
2017
Defining the genetic drivers of cancer progression is a key in understanding disease biology and developing effective targeted… Expand
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Highly Cited
2016
Highly Cited
2016
The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9 is implicated in prostate cancer… Expand
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2015
2015
Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using… Expand
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2015
2015
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted… Expand
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Highly Cited
2013
Highly Cited
2013
Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this pathway is an attractive therapeutic… Expand
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Highly Cited
2013
Highly Cited
2013
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However… Expand
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