LGK974

Known as: PORCN inhibitor LGK974 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
024620132017

Papers overview

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2018
2018
WNT signalling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by… (More)
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2017
2017
In this study, LPS-induced inflammatory responses in BEAS-2B human bronchial epithelial cells and human umbilical vein… (More)
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2017
2017
In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However… (More)
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2016
2016
Notch signaling can promote tumorigenesis in the nervous system and plays important roles in stem-like cancer cells. However… (More)
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2015
2015
Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using… (More)
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2015
2015
The pan-PI3K inhibitors are one treatment option for triple-negative breast cancer (TNBC). However, this treatment is ineffective… (More)
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2015
2015
We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted… (More)
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2015
2015
Nuclear receptor binding protein 1 (NRBP1) is a highly conserved protein that is ubiquitously expressed across cell types in… (More)
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Highly Cited
2013
Highly Cited
2013
Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this pathway is an attractive therapeutic… (More)
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Highly Cited
2013
Highly Cited
2013
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However… (More)
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