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LGK974

Known as: PORCN inhibitor LGK974 
National Institutes of Health

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3 relations
Porcupine Inhibitor WNT974

Broader (2)

PyrazinesPyridines

Papers overview

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2020
2020
Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug
Colorectal cancer (CRC) is one of the most common gastrointestinal malignancies. Despite recent advances in the treatment for CRC… 
2019
2019
Abstract C01: Porcupine inhibition redirects mitochondrial metabolism in Wnt-dependent pancreatic cancer
Wnt/β-catenin signaling plays important roles in pancreatic ductal adenocarcinoma (PDA) tumor initiation and progression via… 
2018
2018
Abstract CT175: Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors
Background: Dysregulated Wnt/β-catenin signaling has been linked to several cancers, including pancreatic cancer (PC) and… 
2018
2018
Abstract LB-036: Targeting the WNT-pathway in 3D-cultures of pancreatic cancer biopsies
Creating patient-derived xenograft (PDX) models from human cancers allows bio-banking, propagation, characterization and drug… 
2017
2017
Mechanical Loading As Potential Treatment For Wnt inhibitor Induced Bone Loss
Wnt signaling pathway has been shown to play a role in bone homeostasis (Figure 1) and carcinogenesis. On the one hand, a… 
2016
2016
Abstract 2515: Pharmacological WNT-inhibition acts synergistically with chemo- and radiotherapy by overcoming treatment-resistance in glioma stem cells
Objective: Glioma Stem Cells (GSCs) are considered to be responsible for Glioblastoma9s (GBM’s) dismal prognosis. WNT signaling… 
2016
2016
Abstract 4119: Inhibition of PORCN prolongs metastasis free survival in a mouse model of Ewing sarcoma
Metastatic disease is the most important factor in determining the survival of patients with Ewing sarcoma (ES). Although… 
2014
2014
Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor
BCR-ABL tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). However, TKIs are… 
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