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LGK974

Known as: PORCN inhibitor LGK974 
National Institutes of Health

Related topics

Related topics

3 relations
Porcupine Inhibitor WNT974

Broader (2)

PyrazinesPyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract C01: Porcupine inhibition redirects mitochondrial metabolism in Wnt-dependent pancreatic cancer
Wnt/β-catenin signaling plays important roles in pancreatic ductal adenocarcinoma (PDA) tumor initiation and progression via… 
2018
2018
Abstract LB-036: Targeting the WNT-pathway in 3D-cultures of pancreatic cancer biopsies
Creating patient-derived xenograft (PDX) models from human cancers allows bio-banking, propagation, characterization and drug… 
2017
2017
Mechanical Loading As Potential Treatment For Wnt inhibitor Induced Bone Loss
Wnt signaling pathway has been shown to play a role in bone homeostasis (Figure 1) and carcinogenesis. On the one hand, a… 
2016
2016
Abstract 4119: Inhibition of PORCN prolongs metastasis free survival in a mouse model of Ewing sarcoma
Metastatic disease is the most important factor in determining the survival of patients with Ewing sarcoma (ES). Although… 
2014
2014
Inhibition of CML Stem Cell Growth By Targeting WNT Signaling Using a Porcupine Inhibitor
BCR-ABL tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML). However, TKIs are… 
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