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Porcupine Inhibitor WNT974

Known as: 2-(2,3-Dimethyl-[2,4-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, WNT974 
An orally available inhibitor of porcupine (PORCN), with potential antineoplastic activity. Upon oral administration, WNT974 binds to and inhibits… 
National Institutes of Health

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2 relations
LGK974NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract CT175: Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors
Background: Dysregulated Wnt/β-catenin signaling has been linked to several cancers, including pancreatic cancer (PC) and… 
2016
2016
The Diagnosis and Surgical Management of Intracardiac Quill Foreign Body in a Dog.
A dog was referred to Alta Vista Animal Hospital with a porcupine quill penetrating the right ventricle. The presenting complaint… 
2015
2015
Abstract C45: Phase I study of WNT974, a first-in-class Porcupine inhibitor, in advanced solid tumors
Background: Aberrant Wnt pathway activation is critical for initiation and maintenance of multiple tumor types, yet therapeutic… 
2015
2015
Septic Tenosynovitis Caused by Porcupine Quills: Clinical and Diagnostic Findings, Treatment, and Long-Term Outcome in Seven Horses
2014
2014
Jejunal perforation due to porcupine quill ingestion in a horse.
An 8-month-old Andalusian filly was treated for jejunal perforations due to ingestion of a porcupine quill. During exploratory… 
1984
1984
RRS Frederick Russell Cruise 6/84 (IOS Cruise 519) : 7-13 April 1984. Benthic biology of the Porcupine Seabight
1983
1983
RRS Challenger Cruise 10/82, 15-26 July 1982. Benthic biology of the Porcupine Seabight
1958
1958
Intraperitoneal foreign body granuloma caused by a porcupine quill.
1947
1947
Collines Porcupine, Alberta
1937
1937
Les collines Porcupine, Alberta
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