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LGD 1069

Known as: LGD-1069, LGD1069 
National Institutes of Health

Related topics

Related topics

2 relations
Targretin

Broader (1)

bexarotene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Relaxant effect of all-trans-retinoic acid via NO-sGC-cGMP pathway and calcium-activated potassium channels in rat mesenteric artery.
Intraperitoneal injection of all-trans-retinoic acid (ATRA) results in a reduction of blood pressure in spontaneously… 
2013
2013
Bexarotene Induces Cellular Senescence in MMTV-Neu Mouse Model of Mammary Carcinogenesis
Previous studies have shown that retinoids and rexinoids can prevent breast cancer in animal models and in women with increased… 
2012
2012
Divergent teratogenicity of agonists of retinoid X receptors in embryos of zebrafish (Danio rerio)
Zebrafish (Danio rerio) embryos were comparably exposed to seven known agonists of retinoid X receptors (RXRs) including two… 
2005
2005
The retinoid X receptor agonist bexarotene (Targretin) synergistically enhances the growth inhibitory activity of cytotoxic drugs in non-small cell lung cancer cells.
2005
2005
Retinoids suppress premalignant MCF10AT but not malignant MCF10CA1a breast epithelial cells in vivo. Role of retinoic acid receptor beta2 expression.
2001
2001
Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines.
Clinical studies have demonstrated that retinoids, including retinol (Vitamin A) and its synthetic derivatives, can eradicate… 
2001
2001
Where to next with retinoids for cancer therapy?
The report by Adamson and colleagues describes a Phase 1 trial in children of 9- cis- RA[2][1] [(1)][2] . This report follows by… 
2000
2000
Receptor mechanisms mediating differentiation and proliferation effects of retinoids on neuroblastoma cells
1997
1997
Potentiation of VD-induced monocytic leukemia cell differentiation by retinoids involves both RAR and RXR signaling pathways
Retinoids and vitamin D (VD) cooperate to induce the differentiation and inhibit the proliferation of human myelomonocytic… 
1997
1997
Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry.
LGD1069 (Targretin), a retinoid "X" receptor-selective ligand, or rexinoid, is in clinical trials for treating cancer… 
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