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Targretin

Known as: Elan brand of bexarotene, Ligand brand of bexarotene 
National Institutes of Health

Related topics

Related topics

5 relations
LGD 1069bexarotene 0.01 MG/MG Topical Gel [Targretin]bexarotene/interferon alfa

Broader (2)

Tetrahydronaphthalenesbexarotene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease.
We present the effects of Targretin® (bexarotene) on cognition and biomarkers in a patient with mild Alzheimer's disease (AD… 
2013
2013
Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models”
Cramer et al. (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid… 
2013
2013
Effects on Gene Expression in Rat Liver after Administration of RXR Agonists: UAB30, 4-Methyl-UAB30, and Targretin (Bexarotene)
Examination of three retinoid X receptor (RXR) agonists [Targretin (TRG), UAB30, and 4-methyl-UAB30 (4-Me-UAB30)] showed that all… 
Highly Cited
2007
Highly Cited
2007
Short-term Modulation of Cell Proliferation and Apoptosis and Preventive/Therapeutic Efficacy of Various Agents in a Mammary Cancer Model
Purpose: The methylnitrosourea (MNU)-induced mammary cancer model in rats is similar to estrogen receptor–positive breast cancer… 
2006
2006
Prevention of mouse lung tumors by targretin
Targretin has indicated chemotherapeutic activity against nonsmall‐cell lung cancer and chemoprevention in rat mammary gland… 
2006
2006
Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide
A rexinoid, targretin, and two retinoids, 9-cis retinoic acid (9cRA) and 4-hydroxyphenylretinamide (4HPR), were examined for… 
Highly Cited
2006
Highly Cited
2006
Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers.
A number of retinoid X receptor (RXR) agonists have proven to be highly effective in preventing methylnitrosourea (MNU) induced… 
2004
2004
Synergistic effect of a retinoid X receptor-selective ligand bexarotene (LGD1069, Targretin) and paclitaxel (Taxol) in mammary carcinoma
We have previously shown that the retinoid X receptor (RXR) ligand bexarotene (LGD1069, Targretin) is efficacious as a… 
2004
2004
Efficacy of Targretin on methylnitrosourea-induced mammary cancers: prevention and therapy dose-response curves and effects on proliferation and apoptosis.
Various aspects of the chemopreventive and chemotherapeutic properties of the RXR receptor agonist Targretin (LGD 1069) were… 
2001
2001
Abrogation of transforming growth factor-alpha/epidermal growth factor receptor autocrine signaling by an RXR-selective retinoid (LGD1069, Targretin) in head and neck cancer cell lines.
Clinical studies have demonstrated that retinoids, including retinol (Vitamin A) and its synthetic derivatives, can eradicate… 
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