bexarotene

Known as: 4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoic acid, 3-methyl TTNEB, P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid 
A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Alzheimer's disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the brain, a process normally facilitated… (More)
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Highly Cited
2011
Highly Cited
2011
UNLABELLED The Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) trial represents the… (More)
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Review
2009
Review
2009
Retinoids are biologically active derivatives of vitamin A, which play essential roles in embryonic or adult cell behavior… (More)
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2009
2009
BACKGROUND Bexarotene (Targretin) is a synthetic retinoid which is licensed for the treatment of advanced refractory cutaneous T… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE To evaluate the activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid) in… (More)
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Highly Cited
2007
Highly Cited
2007
On October 6, 2006, the U.S. Food and Drug Administration granted regular approval to vorinostat (Zolinza(R); Merck & Co., Inc… (More)
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2007
2007
OBJECTIVE Therapy with the retinoid X receptor agonist bexarotene is associated with hypothyroidism caused by decreased pituitary… (More)
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2002
2002
BACKGROUND Bexarotene (Targretin oral capsules), the first RXR-selective retinoid "rexinoid" approved for all stages of cutaneous… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE Cutaneous T-cell lymphomas (CTCL) are malignancies of T cells appearing as skin lesions and are responsive to retinoid… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVES To determine the safety and efficacy of oral bexarotene (Targretin capsules; Ligand Pharmaceuticals Incorporated, San… (More)
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