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LATS2 protein, human

Known as: Large Tumor Suppressor 2, Serine/Threonine-Protein Kinase LATS2, LATS2 Protein 
Serine/threonine-protein kinase LATS2 (1088 aa, ~120 kDa) is encoded by the human LATS2 gene. This protein is involved in both serine/threonine… 
National Institutes of Health

Related topics

Related topics

15 relations
Cell NucleusEnzyme GeneG1/S Transition CheckpointHomo sapiens

Broader (2)

Protein-Serine-Threonine KinasesTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer.
Highly Cited
2016
Highly Cited
2016
Long Noncoding RNA PVT1 Promotes Non–Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression
Long noncoding RNAs (lncRNA) are a novel class of transcripts with no protein coding capacity, but with diverse functions in… 
Highly Cited
2016
Highly Cited
2016
Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells
Recently, long non-coding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes, including cell… 
Highly Cited
2011
Highly Cited
2011
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
pRB-mediated inhibition of cell proliferation is a complex process that depends on the action of many proteins. However, little… 
Highly Cited
2009
Highly Cited
2009
Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinoma.
Squamous cell carcinomas of head and neck (HNSCC) are a result of multiple genetic and epigenetic alterations. Epigenetic… 
Highly Cited
2006
Highly Cited
2006
LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.
LATS2 is a human homolog of Drosophila tumor suppressor lats/warts, and encodes a mitotic kinase whose physiological roles remain… 
Highly Cited
2005
Highly Cited
2005
Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers
Purpose: LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the… 
Highly Cited
2005
Highly Cited
2005
Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia
Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia 
Highly Cited
2004
Highly Cited
2004
The centrosomal protein Lats2 is a phosphorylation target of Aurora‐A kinase
Human Lats2, a novel serine/threonine kinase, is a member of the Lats kinase family that includes the Drosophila tumour… 
Highly Cited
2000
Highly Cited
2000
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
We have cloned and characterized LATS2, a novel mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Northern… 
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