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LATS2 protein, human
Known as:
Large Tumor Suppressor 2
, Serine/Threonine-Protein Kinase LATS2
, LATS2 Protein
Â
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Serine/threonine-protein kinase LATS2 (1088 aa, ~120 kDa) is encoded by the human LATS2 gene. This protein is involved in both serine/threonine…Â
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National Institutes of Health
Topic mentions per year
Topic mentions per year
2000-2018
0
10
20
2000
2018
Related topics
Related topics
15 relations
Cell Nucleus
Enzyme Gene
G1/S Transition Checkpoint
Homo sapiens
(More)
Broader (2)
Protein-Serine-Threonine Kinases
Tumor Suppressor Proteins
Related mentions per year
Related mentions per year
1936-2018
1940
1960
1980
2000
2020
LATS2 protein, human
Cell Nucleus
Signal Transduction
Homo sapiens
Phosphotransferases
Protein phosphorylation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
MiR-93 enhances angiogenesis and metastasis by targeting LATS2
Ling Fang
,
William Weidong Du
,
+10 authors
Burton B. Yang
Cell cycle
2012
Here we report that miR-93, a miRNA in the miR-106B~25 cluster, a paralog of the miR-17-92 cluster, was significantly upregulated…Â
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Highly Cited
2011
Highly Cited
2011
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Hideki Murakami
,
Tetsuya Mizuno
,
+10 authors
Yoshitaka S Sekido
Cancer research
2011
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based…Â
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Highly Cited
2011
Highly Cited
2011
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
Murugan Paramasivam
,
Ali S. Sarkeshik
,
John R. Yates
,
Maria Fernandes
,
Dannel McCollum
Molecular biology of the cell
2011
LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth and tumor suppression by…Â
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2011
2011
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
Katrin Tschöp
,
Andrew R. Conery
,
+4 authors
Nicholas Dyson
Genes & development
2011
pRB-mediated inhibition of cell proliferation is a complex process that depends on the action of many proteins. However, little…Â
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Highly Cited
2009
Highly Cited
2009
MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.
Kuen-Haur Lee
,
Y G Goan
,
+5 authors
Pei-Jung Lu
Experimental cell research
2009
LATS2 is a member of the LATS tumor suppressor family. It has been implicated in regulation of the cell cycle and apoptosis…Â
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2009
2009
miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2.
Wha Ja Cho
,
Jeong Min Shin
,
+6 authors
Kye-Seong Kim
Molecules and cells
2009
Previously, we have reported tissue- and stage-specific expression of miR-372 in human embryonic stem cells and so far, not many…Â
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Highly Cited
2006
Highly Cited
2006
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.
Yael Aylon
,
Dan Michael
,
Ayelet Shmueli
,
N. Harumi Yabuta
,
Hiroshi Nojima
,
Moshe Oren
Genes & development
2006
Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of…Â
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Highly Cited
2006
Highly Cited
2006
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
Zheng Jiang
,
Xingang Li
,
+4 authors
Daru Lu
Neuroscience research
2006
LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but their methylation statuses are still…Â
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Highly Cited
2005
Highly Cited
2005
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.
Yuri Takahashi
,
Yasuo Miyoshi
,
+4 authors
Shinzaburo Noguchi
Clinical cancer research : an official journal of…
2005
PURPOSE LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the promoter…Â
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Highly Cited
2003
Highly Cited
2003
Lats2, a putative tumor suppressor, inhibits G1/S transition
Yunfang Li
,
Jing Pei
,
Hong Xia
,
Hengning Ke
,
Hongyan Wang
,
Wufan Tao
Oncogene
2003
Lats2 is a new member of the Lats tumor suppressor family. The human LATS2 gene is located at chromosome 13q11–12, which has been…Â
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