FAQ

LATS2 protein, human

Known as: Large Tumor Suppressor 2, Serine/Threonine-Protein Kinase LATS2, LATS2 Protein 
Serine/threonine-protein kinase LATS2 (1088 aa, ~120 kDa) is encoded by the human LATS2 gene. This protein is involved in both serine/threonine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
0102020002018

Related topics

Related topics

15 relations
Cell NucleusEnzyme GeneG1/S Transition CheckpointHomo sapiens
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Broader (2)

Protein-Serine-Threonine KinasesTumor Suppressor Proteins

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
LATS2 protein, human
Cell Nucleus
Signal Transduction
Homo sapiens
Phosphotransferases
Protein phosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
MiR-93 enhances angiogenesis and metastasis by targeting LATS2
Here we report that miR-93, a miRNA in the miR-106B~25 cluster, a paralog of the miR-17-92 cluster, was significantly upregulated… (More)
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Highly Cited
2011
Highly Cited
2011
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based… (More)
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Highly Cited
2011
Highly Cited
2011
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
LATS2 kinase functions as part of the Hippo pathway to promote contact inhibition of growth and tumor suppression by… (More)
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2011
2011
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
pRB-mediated inhibition of cell proliferation is a complex process that depends on the action of many proteins. However, little… (More)
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Highly Cited
2009
Highly Cited
2009
MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.
LATS2 is a member of the LATS tumor suppressor family. It has been implicated in regulation of the cell cycle and apoptosis… (More)
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2009
2009
miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2.
Previously, we have reported tissue- and stage-specific expression of miR-372 in human embryonic stem cells and so far, not many… (More)
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Highly Cited
2006
Highly Cited
2006
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.
Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of… (More)
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Highly Cited
2006
Highly Cited
2006
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle, but their methylation statuses are still… (More)
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Highly Cited
2005
Highly Cited
2005
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.
PURPOSE LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the promoter… (More)
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Highly Cited
2003
Highly Cited
2003
Lats2, a putative tumor suppressor, inhibits G1/S transition
Lats2 is a new member of the Lats tumor suppressor family. The human LATS2 gene is located at chromosome 13q11–12, which has been… (More)
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