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LATS2 protein, human

Known as: Large Tumor Suppressor 2, Serine/Threonine-Protein Kinase LATS2, LATS2 Protein 
Serine/threonine-protein kinase LATS2 (1088 aa, ~120 kDa) is encoded by the human LATS2 gene. This protein is involved in both serine/threonine… Expand
National Institutes of Health

Related topics

Related topics

15 relations
Cell NucleusEnzyme GeneG1/S Transition CheckpointHomo sapiens
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Broader (2)

Protein-Serine-Threonine KinasesTumor Suppressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Long Noncoding RNA PVT1 Promotes Non–Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression
Long noncoding RNAs (lncRNA) are a novel class of transcripts with no protein coding capacity, but with diverse functions in… Expand
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Highly Cited
2013
Highly Cited
2013
MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1.
Dysregulation of microRNAs has a critical role in cancer progression. Here we identify an intronic microRNA, miR-135b that is… Expand
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Highly Cited
2011
Highly Cited
2011
A kinase shRNA screen links LATS2 and the pRB tumor suppressor.
pRB-mediated inhibition of cell proliferation is a complex process that depends on the action of many proteins. However, little… Expand
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Highly Cited
2011
Highly Cited
2011
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
The Hippo pathway kinase LATS2 promotes contact inhibition of growth. How LATS2 is activated in response to changes in cell… Expand
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Highly Cited
2011
Highly Cited
2011
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Malignant mesothelioma (MM) is an aggressive neoplasm associated with asbestos exposure. We carried out genome-wide array-based… Expand
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Highly Cited
2010
Highly Cited
2010
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.
MicroRNAs (miRNAs) regulate gene expression. It has been suggested that obtaining miRNA expression profiles can improve… Expand
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Highly Cited
2009
Highly Cited
2009
MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.
LATS2 is a member of the LATS tumor suppressor family. It has been implicated in regulation of the cell cycle and apoptosis… Expand
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Highly Cited
2005
Highly Cited
2005
Down-Regulation of LATS1 and LATS2 mRNA Expression by Promoter Hypermethylation and Its Association with Biologically Aggressive Phenotype in Human Breast Cancers
Purpose: LATS1 and LATS2 are tumor suppressor genes implicated in the regulation of cell cycle. Methylation status of the… Expand
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Highly Cited
2005
Highly Cited
2005
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Originally identified in Drosophila melanogaster, the Warts(Wts)/Lats protein kinase has been proposed to function with two other… Expand
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Highly Cited
2004
Highly Cited
2004
The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.
Human Lats2, a novel serine/threonine kinase, is a member of the Lats kinase family that includes the Drosophila tumour… Expand
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