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L870810

Known as: L-870,810 
 
National Institutes of Health

Papers overview

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2015
2015
The purpose was to propose two-stage single-compartment models for evaluating dissolution characteristics in distal ileum and… Expand
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2012
2012
Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1,6]naphthyridines (i.e., L-870,810) were one of the… Expand
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Review
2011
Review
2011
Highly active antiretroviral therapy (HAART) significantly decreases plasma viral load, increases CD4+ T-cell counts in HIV-1… Expand
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2009
2009
A three-dimensional model of a complex between HIV-1 integrase (IN), viral DNA, and metal ions that we recently built was used as… Expand
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2008
2008
To gain further insight into the understanding of the antiviral resistance patterns and mechanisms of the integrase strand… Expand
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Review
2007
Review
2007
From the discovery of HIV-1 integrase (IN) inhibitors using enzyme-based assays in 1992, it has taken 15 years to achieve success… Expand
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2007
2007
Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to inhibit human… Expand
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2007
2007
BackgroundTreatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination… Expand
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2005
2005
Because of its unique role in the viral replication process, HIV-1 integrase (IN) is an important antiretroviral drug target. The… Expand
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Highly Cited
2004
Highly Cited
2004
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new… Expand
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