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L870810

Known as: L-870,810 
National Institutes of Health

Papers overview

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2015
2015
The purpose was to propose two-stage single-compartment models for evaluating dissolution characteristics in distal ileum and… Expand
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2012
2012
Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1,6]naphthyridines (i.e., L-870,810) were one of the… Expand
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Review
2011
Review
2011
Highly active antiretroviral therapy (HAART) significantly decreases plasma viral load, increases CD4+ T-cell counts in HIV-1… Expand
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Highly Cited
2009
Highly Cited
2009
A three‐dimensional model of a complex between HIV‐1 integrase (IN), viral DNA, and metal ions that we recently built was used as… Expand
2008
2008
ABSTRACT To gain further insight into the understanding of the antiviral resistance patterns and mechanisms of the integrase… Expand
Review
2007
Review
2007
From the discovery of HIV-1 integrase (IN) inhibitors using enzyme-based assays in 1992, it has taken 15 years to achieve success… Expand
2007
2007
ABSTRACT Integrase is actively studied as an antiviral target, but many inhibitors selected from biochemical screens fail to… Expand
2007
2007
BackgroundTreatment of feline immunodeficiency virus (FIV) infection has been hampered by the absence of a specific combination… Expand
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Highly Cited
2005
Highly Cited
2005
Because of its unique role in the viral replication process, HIV-1 integrase (IN) is an important antiretroviral drug target. The… Expand
Highly Cited
2004
Highly Cited
2004
The increasing incidence of resistance to current HIV-1 therapy underscores the need to develop antiretroviral agents with new… Expand
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