Two-Stage Single-Compartment Models to Evaluate Dissolution in the Lower Intestine.


The purpose was to propose two-stage single-compartment models for evaluating dissolution characteristics in distal ileum and ascending colon, under conditions simulating the bioavailability and bioequivalence studies in fasted and fed state by using the mini-paddle and the compendial flow-through apparatus (closed-loop mode). Immediate release products of… (More)
DOI: 10.1002/jps.24485

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