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L3MBTL3 gene

Known as: KIAA1798, L3MBTL3, l(3)mbt-like 3 (Drosophila) 
 
National Institutes of Health

Related topics

Related topics

1 relation
L3MBTL2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract 3658: Characterization of the role of L3MBTL3 in medulloblastoma tumorigenesis
Medulloblastoma is the most common malignant brain tumor of childhood. Therapeutic approaches to medulloblastoma have led to… Expand
2019
2019
OS12.3 L3MBTL3 is a novel suppressor of medulloblastoma tumorigenesis
 
2018
2018
Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4DCAF5 ubiquitin ligase
SOX2 is a dose-dependent master stem cell protein that controls the self-renewal and pluripotency or multipotency of embryonic… Expand
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2017
2017
RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1
Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon… Expand
Highly Cited
2016
Highly Cited
2016
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation
Genome-wide study in Germans identifies four novel multiple sclerosis risk genes and confirms already known gene loci. We… Expand
2016
2016
The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer.
L3MBTL3 recognizes mono- and dimethylated lysine residues on histone tails. The recently reported X-ray cocrystal structures of… Expand
Highly Cited
2013
Highly Cited
2013
Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain
We describe the discovery of UNC1215, a potent and selective chemical probe for the methyl-lysine (Kme) reading function of… Expand
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Highly Cited
2013
Highly Cited
2013
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
Lysine methylation is a key epigenetic mark, the dysregulation of which is linked to many diseases. Small-molecule antagonism of… Expand
Highly Cited
2013
Highly Cited
2013
Development of GMDR-GPU for Gene-Gene Interaction Analysis and Its Application to WTCCC GWAS Data for Type 2 Diabetes
Although genome-wide association studies (GWAS) have identified a significant number of single-nucleotide polymorphisms (SNPs… Expand
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2013
2013
The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain… Expand
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