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L-melphalanyl-p-L-fluorophenylalanine ethyl ester

Known as: Melphalan-Flufenamide Prodrug 
A melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Dipeptides

Narrower (1)

J1 compound

Papers overview

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2007
2007
The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo
Neuroblastoma is the most common extracranial solid tumor of childhood. The activity of J1 (l-melphalanyl-p-l-fluorophenylalanine… 
2005
2005
Feline calicivirus protein synthesis investigated by Western blotting
SummaryWe have used Western blotting to examine the accumulation of feline calicivirus proteins within the infected cell… 
2003
2003
Activity of Hydrolytic Enzymes in Tumour Cells is a Determinant for Anti-tumour Efficacy of the Melphalan Containing Prodrug J1
Recently, we presented a series of melphalan containing di- and tripeptides with high cytotoxic activity and J1 (l-melphalanyl-p… 
1998
1998
Comparison of the cytotoxic activity of melphalan with L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine in human tumour cell lines and primary cultures of tumour cells from patients.
m-L-sarcolysin (m-L-SL) is an isomer of melphalan (Mel) with the di(2-chloroethyl) amino group being substituted in the meta… 
1988
1988
Biochemical and Autoradiographic Study of Cerebral Protein Synthesis with [18F]‐ and [14C]Fluorophenylalanine
Fluorine‐18‐labeled ortho or para isomers of l‐fluorophenylalanine were used in double‐label experiments together with l‐[3H… 
1983
1983
Transport of antimicrobial agents using peptide carrier systems: anticandidal activity of m-fluorophenylalanine--peptide conjugates.
A series of di- and tripeptides containing D- and L-m-fluorophenylalanine was prepared and tested in vitro for the ability to… 
1976
1976
Peptide utilization by Pseudomonas putida and Pseudomonas maltophilia.
Pseudomonas putida assimilates peptides and hydrolyses them with intracellular peptidases. Amino acid auxotrophs (his, trp, thr… 
Highly Cited
1964
Highly Cited
1964
Inhibition of Interferon Action by p-Fluorophenylalanine
1964
1964
EFFECTS OF P-FLUOROPHENYLALANINE ON LACTOSE-INDUCED BETA-GALACTOSIDASE SYNTHESIS IN RESTING-CELL SUSPENSIONS OF ESCHERICHIA COLI.
1953
1953
The assimilation of amino acids by bacteria. 19. The inhibition of phenylalanine incorporation in Staphylococcus aureus by chloramphenicol and p-chlorophenylalanine.
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