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L-NDDP

Known as: Liposomal Neodecanoic Acid Platinum Complex, Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II), liposomal-NDDP 
A synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin… Expand
National Institutes of Health

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DNADNA CrosslinkingDNA Synthesis InhibitionRNA Transcription Inhibition
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Papers overview

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Review
2012
Review
2012
New Cisplatin Analogues in Development
SummaryCisplatin was discovered to have cytotoxic properties in the 1960s, and by the end of the 1970s it had earned a place as… Expand
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Review
2007
Review
2007
Broadening the clinical use of platinum drug–based chemotherapy with new analogues
The three platinum-containing drugs that have been thus far approved by the FDA – cisplatin, carboplatin and oxaliplatin – have… Expand
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2006
2006
A Phase 2 trial of the liposomal DACH platinum L-NDDP in patients with therapy-refractory advanced colorectal cancer
Purpose: L-NDDP (AroplatinTM) is a liposomal formulation of cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II… Expand
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2005
2005
Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma.
PURPOSE To determine pathologic response rates to liposome-entrapped cis-bisneodecanoato-trans-R,R-1,2-diaminocyclohexane… Expand
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2001
2001
A high-throughput screen for identifying transmembrane pore-forming peptides.
We have developed a visual microwell plate assay for rapid, high-throughput screening for membrane-disrupting molecules such as… Expand
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1997
1997
Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions.
cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) (NDDP) is a lipophilic non-cross-resistant platinum compound… Expand
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1991
1991
Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato) platinum(II). Evidence for a novel rearrangement involving platinum…
The complex (R,R-1,2-diaminocyclohexane)bis(shikimato)platinum(II) (shikimato = the anion of 3R,4S,5R-trihydroxy-1-cyclohexene-1… Expand
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1990
1990
Topical liposomal delivery of antibiotics in soft tissue infection.
A new drug delivery system (lipid microcarriers) was studied in an experimental model of infected soft tissue wounds. Superficial… Expand
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1990
1990
Phase I clinical and pharmacological study of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II).
cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum++ +(II) (NDDP) is a liposome dependent cisplatin analogue since the… Expand
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1987
1987
Treatment and prophylaxis of experimental liver metastases of M5076 reticulosarcoma with cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) encapsulated in multilamellar vesicles.
cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum++ +-(II) (NDDP) was encapsulated in multilamellar vesicles composed… Expand
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