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L 754142

Known as: L-754,142 
National Institutes of Health

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1 relation

Broader (1)

Acetamides

Papers overview

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2003
2003
Role of prostaglandin, endothelin and sympathetic nervous system on the l-NAME-induced pressor responses in spontaneously hypertensive rats
Highly Cited
2001
Highly Cited
2001
Chronic endothelin-1 blockade reduces sympathetic nerve activity in rabbits with heart failure.
Endothelin-1 (ET-1) is elevated in chronic heart failure (CHF). In this study, we determined the effects of chronic ET-1 blockade… 
2001
2001
The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure.
The diastolic dysfunction present at rest in congestive heart failure (CHF) is exacerbated during exercise (Ex). Increases in… 
2001
2001
The endothelin receptor antagonist, L-754,142 does not prevent cyclosporine a-induced osteopenia in rats
Cyclosporine A (CsA) is a potent immunosuppressive agent widely used to prevent allograft rejection.In vivo administration of CsA… 
1999
1999
Endogenous endothelin-1 depresses left ventricular systolic and diastolic performance in congestive heart failure.
Endothelin-1 (ET-1) is a positive inotrope in normal hearts; however, the direct cardiac effects of endogenous ET-1 in congestive… 
1999
1999
Characterization of endothelin receptors in the anesthetized ferret: a novel model for investigating the functional ET(B) receptor subtypes.
The pharmacology of endothelin (ET)-1, big ET-1, ET-3, and S6c were characterized in the anesthetized ferret to assess whether… 
1998
1998
Role of endothelin and nitric oxide imbalance in the pathogenesis of hypoxia-induced arterial hypertension.
BACKGROUND We have recently demonstrated that prolonged hypobaric hypoxia can lead to a hematocrit-independent sustained arterial… 
1998
1998
Contribution of endothelin to the acute pressor response of L-NAME in stroke-prone spontaneously hypertensive rats.
In this study, we examined whether endothelin (ET) plays a role in the short-term increase in mean arterial pressure (MAP) after… 
1995
1995
Pharmacology of L-754,142, a highly potent, orally active, nonpeptidyl endothelin antagonist.
L-754,142, (-)-N-(4-iso-propylbenzenesulfonyl)-alpha-(4-carboxyl-2-n-propy lphenoxy)-3,4- methylenedioxyphenylacetamide, is a… 
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