The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure.

@article{Cheng2001TheRO,
  title={The role of ANG II and endothelin-1 in exercise-induced diastolic dysfunction in heart failure.},
  author={C P Cheng and Tomohiko Ukai and Katsuya Onishi and Nobuyuki Ohte and Makoto Suzuki and Z S Zhang and H J Cheng and Hideo Tachibana and Akihiko Igawa and William James Little},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 4},
  pages={H1853-60}
}
The diastolic dysfunction present at rest in congestive heart failure (CHF) is exacerbated during exercise (Ex). Increases in circulating ANG II and endothelin-1 (ET-1) during Ex may contribute to this response. We assessed the effect of Ex on circulating plasma levels of ANG II and ET-1 and left ventricular (LV) dynamics before and after pacing-induced CHF at rest and during Ex in nine conscious, instrumented dogs. Before CHF, there were modest increases in circulating levels of ANG II (but… CONTINUE READING