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L 744832

Known as: L 744,832, L-744,832, L-744832 
A farnesyl transferase inhibitors.
National Institutes of Health

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Related topics

2 relations

Broader (1)

Methionine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Prenyltransferases Regulate CD20 Protein Levels and Influence Anti-CD20 Monoclonal Antibody-mediated Activation of Complement-dependent Cytotoxicity*
Background: The influence of farnesyltransferase inhibitors (FTIs) on CD20 levels is unknown. Results: FTIs increase CD20… 
2008
2008
A combined treatment of HeLa cells with the farnesyl protein transferase inhibitor L‐744,832 and cisplatin significantly increases the therapeutic effect as compared to cisplatin monotherapy
Activating mutations of Ras that frequently occur during malignant transformation, enhance growth‐promoting signal transduction… 
2005
2005
Effect of the Farnesyl Transferase Inhibitor L-744,832 on the Colon Cancer Cell Line DLD-1 and Its Combined Use with Radiation and 5-FU
Background: Ras oncogenes are found in 25% of human tumors and they significantly affect prognosis. One of the major fields… 
2004
2004
Potentiated antitumor effects of a combination therapy with a farnesyltransferase inhibitor L-744,832 and butyrate in vitro.
Farnesyltransferase inhibitors, butyrate and butyric acid derivatives have previously been reported to exert anti-tumor activity… 
2002
2002
PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells.
2001
2001
Farnesyl:protein transferase inhibitors as potential agents for the management of human prostate cancer
The effects of farnesyl:protein transferase inhibitors (FTIs) were evaluated against hormone-dependent and hormone-independent… 
Highly Cited
2000
Highly Cited
2000
Farnesyltransferase Inhibitor Induces Rapid Growth Arrest and Blocks p70s6k Activation by Multiple Stimuli*
We have previously shown that the peptidomimetic farnesyltransferase inhibitor L-744,832 (FTI) inhibits p70s6k activation and… 
2000
2000
by a Farnesyl : Protein Transferase Inhibitor Develop Mammary Carcinomas That Can Be Growth-inhibited B Transgenic Mice ras Mouse Mammary Tumor Virus-Ki-Updated
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction… 
1999
1999
The Farnesyltransferase Inhibitor L‐744,832 Inhibits the Growth of Astrocytomas through a Combination of Antiproliferative, Antiangiogenic, and Proapoptotic Activities
The 21-kD cellular protein Ras is known to play a critical role in a wide range of cellular events, including proliferation… 
1999
1999
Inhibition of DNA Synthesis by a Farnesyltransferase Inhibitor Involves Inhibition of the p 70 s 6 k Pathway *
Previously, the protein farnesyltransferase inhibitor (FTI), L-744,832, has been shown to inhibit the proliferation of a number… 
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