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L 655,708

Known as: L-655708, L-655,708, L655708 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Imidazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Comparison of rapid and long-lasting antidepressant effects of negative modulators of α5-containing GABAA receptors and (R)‑ketamine in a chronic social defeat stress model
Highly Cited
2015
Highly Cited
2015
Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors
Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective… 
2014
2014
Evidence for the participation of peripheral α5 subunit-containing GABAA receptors in GABAA agonists-induced nociception in rats.
Review
2011
Review
2011
GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.
Benzodiazepine site agonists (such as diazepam) are well-known to impair cognition. Since benzodiazepines exert their effects via… 
2011
2011
α5GABAA receptors regulate hippocampal sharp wave–ripple activity in vitro
Highly Cited
2010
Highly Cited
2010
Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals
Highly Cited
2007
Highly Cited
2007
Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.
Fast inhibitory synaptic transmission is primarily mediated by synaptically released gamma-aminobutyric acid (GABA) acting on… 
2006
2006
RAT PHARMACOKINETICS AND PHARMACODYNAMICS OF A SUSTAINED RELEASE FORMULATION OF THE GABAA α5-SELECTIVE COMPOUND L-655,708
The pharmacokinetic and pharmacodynamic (i.e., receptor occupancy) properties of L-655,708, a compound with selectivity for α5… 
2004
2004
Behavioral profile of L-655,708, a selective ligand for the benzodiazepine site of GABA-A receptors which contain the α5 subunit, in social encounters between male mice
GABA-A receptor is a transmembrane hetero-oligomeric protein which consists of five subunits, the combination of which confers… 
Highly Cited
1996
Highly Cited
1996
[3H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABAA Receptors which Contain the α5 Subunit
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