[3H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABAA Receptors which Contain the α5 Subunit

@article{Quirk19963HL655708AN,
  title={[3H]L-655,708, a Novel Ligand Selective for the Benzodiazepine Site of GABAA Receptors which Contain the $\alpha$5 Subunit},
  author={K. Quirk and P. Blurton and S. Fletcher and P. Leeson and F. Tang and D. Mellilo and C. Ragan and R. Mckernan},
  journal={Neuropharmacology},
  year={1996},
  volume={35},
  pages={1331-1335}
}
A compound (L-655,708) has been identified which has at least 50-fold selectivity for the benzodiazepine site on GABAA receptors containing an alpha 5 subunit over those containing an alpha 1, alpha 2, alpha 3 or alpha 6 subunit in combination with beta 3 and gamma 2. The compound was radiolabelled with tritium and investigated as a novel radioligand which recognizes the benzodiazepine site of GABAA receptors which contain the alpha 5 subunit. [3H]L-655,708 labels one saturable and specific… Expand
In vivo labelling of α5 subunit-containing GABAA receptors using the selective radioligand [3H]L-655,708
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