• Publications
  • Influence
Cl− uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl−]i in immature neocortical neurones causes GABAA receptor activation toExpand
  • 468
  • 50
GABAergic Depolarization of the Axon Initial Segment in Cortical Principal Neurons Is Caused by the Na–K–2Cl Cotransporter NKCC1
GABAergic terminals of axo-axonic cells (AACs) are exclusively located on the axon initial segment (AIS) of cortical principal neurons, and they are generally thought to exert a powerful inhibitoryExpand
  • 250
  • 29
The cation‐chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus
Earlier studies indicate a crucial role for the interconnected network of intrinsically bursting CA3 pyramidal neurons in the generation of in vivo hippocampal sharp waves (SPWs) and their proposedExpand
  • 135
  • 15
Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase α2 Subunit-Deficient Mice Is Attributable to Abnormal Cl- Homeostasis in Brainstem Neurons
Na+, K+-ATPase α2 subunit gene (Atp1a2) knock-out homozygous mice (Atp1a2-/-) died immediately after birth resulting from lack of breathing. The respiratory-related neuron activity in Atp1a2-/- wasExpand
  • 110
  • 14
Induction of NMDA and GABAA receptor-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons.
To clarify the changes that occur in gamma-aminobutyric acid type A (GABA(A)) receptor-mediated effects and contribute to alterations in the network activities after neuronal injury, we studiedExpand
  • 115
  • 11
  • PDF
Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat.
We have generated transgenic rats expressing an arginine vasopressin (AVP)-enhanced green fluorescent protein (eGFP) fusion gene. The expression of the eGFP gene and strong fluorescence were observedExpand
  • 136
  • 9
  • PDF
Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons.
It is known that GABA, a major inhibitory transmitter in the CNS, acts as an excitatory (or depolarizing) transmitter transiently after intense GABAA receptor activation in adult brains. TheExpand
  • 109
  • 9
  • PDF
Kinetic Properties of Cl− Uptake Mediated by Na+-Dependent K+-2Cl− Cotransport in Immature Rat Neocortical Neurons
GABA, the main inhibitory neurotransmitter in the adult nervous system, evokes depolarizing membrane responses in immature neurons, which are crucial for the generation of early network activity.Expand
  • 135
  • 8
  • PDF
Simultaneous production of homoanatoxin-a, anatoxin-a, and a new non-toxic 4-hydroxyhomoanatoxin-a by the cyanobacterium Raphidiopsis mediterranea Skuja.
A neurotoxin, homoanatoxin-a, was identified from a toxic strain of the cyanobacterium Raphidiopsis mediterranea Skuja (strain LBRI 48) isolated from Lake Biwa, Japan, as the major toxin componentExpand
  • 124
  • 8
Brain‐type creatine kinase activates neuron‐specific K+‐Cl– co‐transporter KCC2
GABA, a major inhibitory neurotransmitter in the adult CNS, is excitatory at early developmental stages as a result of the elevated intracellular Cl– concentration ([Cl–]i). This functional switch isExpand
  • 67
  • 8