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- Publications
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Cl− uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1
- J. Yamada, A. Okabe, H. Toyoda, W. Kilb, H. Luhmann, A. Fukuda
- Biology, Medicine
- The Journal of physiology
- 1 June 2004
GABA is the principal inhibitory neurotransmitter in the mature brain, but during early postnatal development the elevated [Cl−]i in immature neocortical neurones causes GABAA receptor activation to… Expand
GABAergic Depolarization of the Axon Initial Segment in Cortical Principal Neurons Is Caused by the Na–K–2Cl Cotransporter NKCC1
- Stanislav Khirug, J. Yamada, R. Afzalov, J. Voipio, L. Khiroug, K. Kaila
- Chemistry, Medicine
- The Journal of Neuroscience
- 30 April 2008
GABAergic terminals of axo-axonic cells (AACs) are exclusively located on the axon initial segment (AIS) of cortical principal neurons, and they are generally thought to exert a powerful inhibitory… Expand
The cation‐chloride cotransporter NKCC1 promotes sharp waves in the neonatal rat hippocampus
- Sampsa T. Sipilä, S. Schuchmann, J. Voipio, J. Yamada, K. Kaila
- Biology, Medicine
- The Journal of physiology
- 1 June 2006
Earlier studies indicate a crucial role for the interconnected network of intrinsically bursting CA3 pyramidal neurons in the generation of in vivo hippocampal sharp waves (SPWs) and their proposed… Expand
Malfunction of Respiratory-Related Neuronal Activity in Na+, K+-ATPase α2 Subunit-Deficient Mice Is Attributable to Abnormal Cl- Homeostasis in Brainstem Neurons
- K. Ikeda, H. Onimaru, +9 authors K. Kawakami
- Biology, Medicine
- The Journal of Neuroscience
- 24 November 2004
Na+, K+-ATPase α2 subunit gene (Atp1a2) knock-out homozygous mice (Atp1a2-/-) died immediately after birth resulting from lack of breathing. The respiratory-related neuron activity in Atp1a2-/- was… Expand
Induction of NMDA and GABAA receptor-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons.
To clarify the changes that occur in gamma-aminobutyric acid type A (GABA(A)) receptor-mediated effects and contribute to alterations in the network activities after neuronal injury, we studied… Expand
Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat.
- Y. Ueta, H. Fujihara, +8 authors D. Murphy
- Biology, Medicine
- Endocrinology
- 2005
We have generated transgenic rats expressing an arginine vasopressin (AVP)-enhanced green fluorescent protein (eGFP) fusion gene. The expression of the eGFP gene and strong fluorescence were observed… Expand
Synaptically activated Cl- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons.
- Y. Isomura, M. Sugimoto, Y. Fujiwara-Tsukamoto, S. Yamamoto-Muraki, J. Yamada, A. Fukuda
- Chemistry, Medicine
- Journal of neurophysiology
- 1 October 2003
It is known that GABA, a major inhibitory transmitter in the CNS, acts as an excitatory (or depolarizing) transmitter transiently after intense GABAA receptor activation in adult brains. The… Expand
Kinetic Properties of Cl− Uptake Mediated by Na+-Dependent K+-2Cl− Cotransport in Immature Rat Neocortical Neurons
- K. Achilles, A. Okabe, +5 authors W. Kilb
- Biology, Medicine
- The Journal of Neuroscience
- 8 August 2007
GABA, the main inhibitory neurotransmitter in the adult nervous system, evokes depolarizing membrane responses in immature neurons, which are crucial for the generation of early network activity.… Expand
Simultaneous production of homoanatoxin-a, anatoxin-a, and a new non-toxic 4-hydroxyhomoanatoxin-a by the cyanobacterium Raphidiopsis mediterranea Skuja.
- M. Namikoshi, T. Murakami, +5 authors S. Oishi
- Biology, Medicine
- Toxicon : official journal of the International…
- 1 October 2003
A neurotoxin, homoanatoxin-a, was identified from a toxic strain of the cyanobacterium Raphidiopsis mediterranea Skuja (strain LBRI 48) isolated from Lake Biwa, Japan, as the major toxin component… Expand
Brain‐type creatine kinase activates neuron‐specific K+‐Cl– co‐transporter KCC2
- Koichi Inoue, J. Yamada, S. Ueno, A. Fukuda
- Biology, Medicine
- Journal of neurochemistry
- 1 January 2006
GABA, a major inhibitory neurotransmitter in the adult CNS, is excitatory at early developmental stages as a result of the elevated intracellular Cl– concentration ([Cl–]i). This functional switch is… Expand