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Keratoderma, Palmoplantar, Diffuse

Known as: Syndrome, Unna-Thost, Keratosis Palmaris et Plantaris, Thost Unna Syndrome 
An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one… 
National Institutes of Health

Related topics

Related topics

23 relations
Bone callusHyperkeratosisIn BloodIntegumentary system

Narrower (3)

Diffuse palmoplantar keratoderma, Bothnian typeHyperkeratosis of the palms and soles and esophageal papillomasPALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC

Broader (1)

Skin callus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17
Without the N terminus, iRhom proteins cannot properly limit ADAM17 activity, resulting in impaired cancer cell death. Tumor… 
Highly Cited
2014
Highly Cited
2014
iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function.
iRHOM2 is a highly conserved, catalytically inactive member of the Rhomboid family, which has recently been shown to regulate the… 
Highly Cited
2012
Highly Cited
2012
RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome.
Highly Cited
2006
Highly Cited
2006
Pruning-induced tylose development in stems of current-year shoots of Vitis vinifera (Vitaceae).
Tyloses form in xylem vessels in response to various environmental stimuli, but little is known of the kinetics or regulation of… 
Highly Cited
2006
Highly Cited
2006
Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer.
Lung cancer demonstrates the highest mortality in the UK. Previous studies have implicated allelic loss at chromosome 17q in the… 
Highly Cited
2006
Highly Cited
2006
Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression.
Tylosis (focal non-epidermolytic palmoplantar keratoderma) is an autosomal dominant skin disorder that is associated with the… 
Review
1996
Review
1996
Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the…
OBJECTIVES To determine linkage in a pedigree with palmoplantar keratoderma (PPK) associated with squamous cell carcinoma of the… 
Highly Cited
1994
Highly Cited
1994
Tylosis oesophageal cancer mapped
1993
1993
Carcinoma of the esophagus and tylosis. A lethal genetic combination
Hyperkeratosis of the palms and soles (tylosis) is an uncommon genetic disorder. A small number of English families, however… 
Highly Cited
1958
Highly Cited
1958
Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families.
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