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KW 2449

Known as: FLT3/ABL/Aurora Kinase Inhibitor KW-2449, KW-2449, KW2449 
An orally available inhibitor of FMS-related tyrosine kinase 3 (FLT3, STK1, or FLK2), the tyrosine kinase ABL, and aurora kinases, with potential… Expand
National Institutes of Health

Papers overview

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2019
2019
KCC2 expression–enhancing small molecules rescue cellular and behavior deficits in human RTT neurons and Mecp2 mutant mice… Expand
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2018
2018
PTEN is a tumor suppressor found mutated in many cancers. From a synthetic lethality drug screen with PTEN-isogenic colorectal… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: The purpose of this study was to determine whether histone deacetylase (HDAC) inhibitors (HDACI) such as vorinostat or… Expand
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Highly Cited
2011
Highly Cited
2011
We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor… Expand
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Highly Cited
2010
Highly Cited
2010
We examined 6 different FMS-like tyrosine kinase-3 (FLT3) inhibitors (lestaurtinib, midostaurin, AC220, KW-2449, sorafenib, and… Expand
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Highly Cited
2009
Highly Cited
2009
Internal tandem duplication mutations of FLT3 (FLT3/ITD mutations) are common in acute myeloid leukemia (AML) and confer a poor… Expand
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Highly Cited
2009
Highly Cited
2009
KW-2449, a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase, is under investigation to treat leukemia patients… Expand
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Review
2009
Review
2009
Imatinib is considered standard therapy for patients with chronic myelogenous leukemia (CML), inducing a high rate of hematologic… Expand
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2008
2008
Background: Activating mutations of FMS-like tyrosine kinase 3 (FLT3) occur in 30% of patients with de novo AML and confer a poor… Expand
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2007
2007
Constitutive activation of FLT3 kinase is associated with poor prognosis in AML and is present in 30–40% of AML patients. KW-2449… Expand
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