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  • Jun Hosogi, Rui Ohashi, +4 authors Takashi Kuwabara
  • Chemistry, Medicine
  • Drug metabolism and pharmacokinetics
  • 2017 (First Published: 1 October 2017)
  • (E)-1-{4-[2-(1H-Indazol-3-yl)vinyl]benzoyl}piperazine (KW-2449) is a novel multikinase inhibitor. During our clinical study, we found that KW-2449 is mainly metabolized to its oxo-piperazine formContinue Reading
  • Shingo Niimi, Kazuhiro Nishimiya, +17 authors Nana Kawasaki
  • Chemistry, Medicine
  • Drug metabolism and pharmacokinetics
  • 2018 (First Published: 1 April 2018)
  • This study was undertaken to evaluate the performance of anti-drug antibody (ADA) assays constructed by each participating company using common samples including ADA, drug and human serum. The ADAContinue Reading
  • Mami Imazato-Hirano, Yoshitaka Taniguchi, +12 authors Noriko Katori
  • Chemistry, Medicine
  • Bioanalysis
  • 2015 (First Published: 1 May 2015)
  • 2015 After almost one and a half years of thorough discussion, ‘The Guideline on Bioanalytical Method (Ligand Binding Assay) Validation in Pharmaceutical Development’ was issued on 1 April 2014 fromContinue Reading