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KNT 127

Known as: KNT-127, KNT127 
National Institutes of Health

Related topics

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1 relation

Broader (1)

Morphinans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Discovery of δ opioid receptor full agonists lacking a basic nitrogen atom and their antidepressant-like effects.
2019
2019
Research and development of κ opioid receptor agonists and δ opioid receptor agonists.
2018
2018
Administration of a delta opioid receptor agonist KNT-127 to the basolateral amygdala has robust anxiolytic-like effects in rats
We previously reported that systemic administration of a selective delta opioid receptor (DOP) agonist, KNT-127, produced potent… 
Review
2018
Review
2018
Delta Opioid Receptor (DOR) Ligands and Pharmacology: Development of Indolo- and Quinolinomorphinan Derivatives Based on the Message-Address Concept.
The pharmacology of the delta opioid receptor (DOR) has lagged, mainly due to the lack of an agonist with high potency and… 
Highly Cited
2016
Highly Cited
2016
β‐Arrestin 2 dependence of δ opioid receptor agonists is correlated with alcohol intake
δ Opioid receptor agonists are being developed as potential treatments for depression and alcohol use disorders. This is… 
2014
2014
In vivo properties of KNT‐127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice
Activation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand‐biased agonism. KNT‐127… 
2014
2014
DOR2-selective but not DOR1-selective antagonist abolishes anxiolytic-like effects of the δ opioid receptor agonist KNT-127
2013
2013
The novel δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines
2012
2012
Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands.
Highly Cited
2010
Highly Cited
2010
Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.
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